Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.56 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.55 |
| ▸ | BCL2 | P10415 | 8/20 | 0.52 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.48 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.43 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29589765 | 0.94 | BCL2 (0.49) | NR1H2ESR2BCL2HSP90AA1HSP90AB1 | |
| SCHEMBL29589794 | 0.88 | BCL2 (0.57) | BCL2 | |
| SCHEMBL31263829 | 0.85 | NR1H2 (0.52) | NR1H2ESR2BCL2HSP90AA1HSP90AB1 | |
| SCHEMBL29590466 | 0.85 | HSP90AA1 (0.47) | HSP90AA1HSP90AB1PRMT5LMNATP53 | |
| SCHEMBL16416972 | 0.85 | HSP90AA1 (0.47) | HSP90AA1HSP90AB1PRMT5LMNATP53 | |
| SCHEMBL29590775 | 0.85 | HSP90AA1 (0.47) | HSP90AA1HSP90AB1MAPK1PRMT5LMNA | |
| SCHEMBL29589768 | 0.84 | TMEM97 (0.57) | BCL2 | |
| SCHEMBL29589933 | 0.84 | BCL2 (0.54) | NR1H2BCL2 | |
| SCHEMBL29589757 | 0.84 | BCL2 (0.42) | BCL2HSP90AA1HSP90AB1NAMPT | |
| SCHEMBL31263676 | 0.84 | BCL2 (0.54) | NR1H2ESR2BCL2HSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119053587-A | 5- [7- (3, 4-Dihydro-1H-isoquinoline-2-carbonyl) -1,2,3,4 tetrahydroisoquinolin-6-yl ] -1H-pyrrole-3-carboxamide derivatives, pharmaceutical compositions containing same and use thereof as pro-apoptotic agents | 法国施维雅药厂 | 2024-11-29 | — | — | CN | disclosed |
| CN-109456324-B | Isoindoline or isoquinoline compounds, process for their preparation and pharmaceutical compositions containing them | 法国施维雅药厂 | 2022-04-22 | — | — | CN | disclosed |