Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 4/20 | 0.49 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 3/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.45 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.44 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.43 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29590139 | 0.94 | NR1H2 (0.56) | BCL2NR1H2NAMPTESR2MAPK1 | |
| SCHEMBL29589757 | 0.90 | BCL2 (0.42) | BCL2NAMPTHSP90AA1HSP90AB1HSP90B1 | |
| SCHEMBL29589723 | 0.87 | BCL2 (0.52) | BCL2 | |
| SCHEMBL28739679 | 0.84 | BCL2 (0.53) | BCL2NR1H2NAMPTHDAC1MAPK1 | |
| SCHEMBL29590813 | 0.84 | BCL2 (0.55) | BCL2 | |
| SCHEMBL29589928 | 0.84 | BCL2 (0.53) | BCL2NR1H2NAMPTHDAC1MAPK1 | |
| SCHEMBL29589831 | 0.84 | OPRM1 (0.43) | BCL2NAMPTHSP90AA1HSP90AB1HSP90B1 | |
| SCHEMBL29590949 | 0.84 | NAMPT (0.42) | BCL2NAMPTHSP90AA1HSP90AB1HSP90B1 | |
| SCHEMBL29589992 | 0.83 | TMEM97 (0.53) | BCL2 | |
| SCHEMBL29589684 | 0.82 | BCL2 (0.51) | BCL2NAMPTHSP90AA1HSP90AB1HSP90B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109456324-B | Isoindoline or isoquinoline compounds, process for their preparation and pharmaceutical compositions containing them | 法国施维雅药厂 | 2022-04-22 | — | — | CN | disclosed |