SCHEMBL29591658

SCHEMBL29591658

CCOC(=O)N1C[C@H](N=[N+]=[N-])C[C@@H]1C(=O)OC

nearest known ligand 0.71

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ MMP2 P08253 3/20 0.71
▸ ANPEP P15144 3/20 0.71
▸ DPP7 Q9UHL4 7/20 0.39
▸ DPP8 Q6V1X1 6/20 0.39
▸ DPP9 Q86TI2 5/20 0.39
▸ DPP4 P27487 5/20 0.39
▸ ALDH1A1 P00352 1/20 0.33
▸ GAA P10253 1/20 0.33
▸ CAPN1 P07384 2/20 0.32
▸ PEPD P12955 2/20 0.32
▸ XPNPEP1 Q9NQW7 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14951723 0.89 MMP2 (0.64) MMP2ANPEPDPP7DPP8DPP9
SCHEMBL30476594 0.83 MMP2 (1.00) MMP2ANPEPDPP7DPP8DPP9
SCHEMBL30370233 0.83 MMP2 (0.79) MMP2ANPEPDPP7DPP8DPP9
SCHEMBL16171927 0.83 MMP2 (1.00) MMP2ANPEPDPP7DPP8DPP9
SCHEMBL14941114 0.83 MMP2 (0.79) MMP2ANPEPDPP7DPP8DPP9
SCHEMBL13768839 0.83 MMP2 (0.70) MMP2ANPEPDPP7DPP8DPP9
SCHEMBL13494285 0.83 MMP2 (0.70) MMP2ANPEPDPP7DPP8DPP9
SCHEMBL13841888 0.83 MMP2 (0.70) MMP2ANPEPDPP7DPP8DPP9
SCHEMBL20215871 0.83 MMP2 (0.70) MMP2ANPEPDPP7DPP8DPP9
SCHEMBL15482322 0.83 MMP2 (0.70) MMP2ANPEPDPP7DPP8DPP9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3833672-B1 TRICYCLIC INHIBITORS OF HEPATITIS B VIRUS OSPEDALE SAN RAFFAELE SRL (IT) 2024-09-18 — — EP disclosed
US-20230076319-A1 INHIBITORS OF HEPATITIS B VIRUS ANTIOS THERAPEUTICS INC (US) 2023-03-09 — — US disclosed
US-11504382-B2 Tricyclic inhibitors of Hepatitis B virus Antios Therapeutics, Inc. (US) 2022-11-22 — — US disclosed
US-20220110943-A1 TRICYCLIC INHIBITORS OF HEPATITIS B VIRUS OSPEDALE SAN RAFFAELE S.R.L. (IT) 2022-04-14 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11504382-B2 Tricyclic inhibitors of Hepatitis B virus HAVCR2, NR1H4, HCCS MMP2 1211/4885ANPEP 1014/4885DPP7 783/4885
US-20220110943-A1 TRICYCLIC INHIBITORS OF HEPATITIS B VIRUS HAVCR2, NR1H4, HCCS MMP2 1211/4885ANPEP 1014/4885DPP7 783/4885
US-20230076319-A1 INHIBITORS OF HEPATITIS B VIRUS HAVCR2, HDGF, SLC10A1 MMP2 710/4885ANPEP 853/4885DPP7 395/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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