Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.63 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.63 |
| ▸ | IDH1 | O75874 | 1/20 | 0.53 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | PRKCB | P05771 | 2/20 | 0.46 |
| ▸ | PRKCA | P17252 | 2/20 | 0.46 |
| ▸ | PRKCH | P24723 | 2/20 | 0.46 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.46 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.46 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.46 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.45 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.44 |
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | CCND1 | P24385 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20624179 | 1.00 | SIRT2 (0.63) | SIRT2SIRT1IDH1MDM2ALDH1A1 | |
| SCHEMBL20624159 | 0.85 | RPS6KB1 (0.51) | SIRT2SIRT1IDH1MDM2PRKCB | |
| SCHEMBL8317402 | 0.82 | SIRT2 (0.63) | SIRT2SIRT1CDK4CCND1 | |
| SCHEMBL20624204 | 0.82 | SIRT2 (0.63) | SIRT2SIRT1GSK3BRPS6KB1CDK4 | |
| SCHEMBL7101072 | 0.79 | CDK4 (0.70) | SIRT2SIRT1ALDH1A1PRKCBDYRK1A | |
| SCHEMBL30958473 | 0.78 | SIRT2 (1.00) | SIRT2SIRT1PRKCBPRKCAPRKCH | |
| SCHEMBL3945882 | 0.78 | SIRT2 (1.00) | SIRT2SIRT1PRKCBPRKCAPRKCH | |
| SCHEMBL7504252 | 0.75 | SIRT2 (0.80) | SIRT2SIRT1PRKCBPRKCAPRKCH | |
| SCHEMBL7194732 | 0.74 | SIRT2 (0.65) | SIRT2SIRT1ALDH1A1NR4A2RPS6KB1 | |
| SCHEMBL9086531 | 0.74 | PRKCB (0.74) | SIRT2IDH1PRKCBPRKCAPRKCH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110218206-B | Bisindolylmaleimide derivative and preparation method and application thereof | 中国海洋大学 | 2022-03-04 | — | — | CN | disclosed |