SCHEMBL29600243

SCHEMBL29600243

Cc1cc(C)nc(C=O)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOS2 P35228 4/20 0.44
NOS3 P29474 2/20 0.44
NOS1 P29475 1/20 0.44
CCR1 P32246 1/20 0.39
ERN1 O75460 1/20 0.38
ALDH1A1 P00352 4/20 0.35
SMN1; SMN2 Q16637 3/20 0.35
MEN1 O00255 2/20 0.35
MAPT P10636 2/20 0.35
KMT2A Q03164 2/20 0.35
KDM4E B2RXH2 1/20 0.35
MPI P34949 1/20 0.35
LCK P06239 1/20 0.33
LMNA P02545 1/20 0.33
NPC1 O15118 1/20 0.33
RAB9A P51151 1/20 0.33
TP53 P04637 1/20 0.33
TERT O14746 1/20 0.33
POLB P06746 1/20 0.32
APOBEC3G Q9HC16 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1646533 1.00 NOS2 (0.44) NOS2NOS3NOS1CCR1ERN1
SCHEMBL10974012 0.87 NOS2 (0.43) NOS2NOS3NOS1CCR1ERN1
2-Pyridinecarboxaldehyde SCHEMBL3867891 0.82 RAB9A (0.42) ALDH1A1SMN1; SMN2MEN1MAPTKMT2A
SCHEMBL25187916 0.77 ALDH1A1 (0.41) NOS2CCR1ERN1ALDH1A1SMN1; SMN2
SCHEMBL29953532 0.77 ALDH1A1 (0.41) NOS2CCR1ERN1ALDH1A1SMN1; SMN2
SCHEMBL12990641 0.77 NOS2 (0.37) NOS2CCR1ERN1ALDH1A1SMN1; SMN2
SCHEMBL3776650 0.77 CCR1 (0.37) CCR1ERN1ALDH1A1MAPTLMNA
SCHEMBL27261834 0.77 CCR1 (0.37) CCR1ERN1ALDH1A1SMN1; SMN2MEN1
SCHEMBL6551038 0.77 POLB (0.37) CCR1ERN1ALDH1A1SMN1; SMN2MEN1
SCHEMBL23444797 0.77 NOS2 (0.37) NOS2NOS3NOS1CCR1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4225765-A2 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR Vertex Pharmaceuticals Incorporated (US) 2023-08-16 EP disclosed
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed
WO-2022076622-A2 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR VERTEX PHARMACEUTICALS INCORPORATED (US) 2022-04-14 WO disclosed