Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.40 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | ACACB | O00763 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.37 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ACACA | Q13085 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL708825 | 1.00 | CHRNB2 (0.40) | CHRNB2CHRNA4ALDH1A3MAP4K4ACACB | |
| SCHEMBL24002863 | 0.84 | CHRNB2 (0.38) | CHRNB2CHRNA4 | |
| SCHEMBL32667064 | 0.83 | CHRNB2 (0.44) | CHRNB2CHRNA4ALDH1A1 | |
| SCHEMBL12923995 | 0.81 | CHRNB2 (0.39) | CHRNB2CHRNA4ACACB | |
| SCHEMBL30187182 | 0.79 | ALOX15 (0.39) | CHRNB2CHRNA4KMT2AALDH1A1 | |
| SCHEMBL2895317 | 0.79 | ALOX15 (0.39) | CHRNB2CHRNA4KMT2AALDH1A1 | |
| SCHEMBL17273947 | 0.78 | TDP1 (0.51) | MAP4K4KMT2AALDH1A1 | |
| SCHEMBL21095850 | 0.78 | TDP1 (0.51) | MAP4K4KMT2AALDH1A1 | |
| SCHEMBL3719165 | 0.78 | ACACB (0.47) | CHRNB2CHRNA4ACACBALDH1A1ACACA | |
| SCHEMBL1000603 | 0.77 | NOS3 (0.46) | ALDH1A3MAP4K4ACACBKMT2APARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025030002-A2 | DGK TARGETING COMPOUNDS AND USES THEREOF | ARVINAS OPERATIONS, INC. (US) | 2025-02-06 | — | — | WO | disclosed |
| EP-4472963-A1 | DGK TARGETING COMPOUNDS AND USES THEREOF | Arvinas Operations, Inc. (US) | 2024-12-11 | — | — | EP | disclosed |
| EP-4232449-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE FOR TREATMENT OF HELMINTHIC INFECTIONS AND DISEASES | Celgene Corporation (US) | 2023-08-30 | — | — | EP | disclosed |
| WO-2022087326-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE FOR TREATMENT OF HELMINTHIC INFECTIONS AND DISEASES | CELGENE CORPORATION (US) | 2022-04-28 | — | — | WO | disclosed |