Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 1.00 |
| ▸ | MAPT | P10636 | 6/20 | 1.00 |
| ▸ | MEN1 | O00255 | 5/20 | 1.00 |
| ▸ | TP53 | P04637 | 4/20 | 1.00 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | TSHR | P16473 | 2/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 2/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 2/20 | 1.00 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 1.00 |
| ▸ | MMP1 | P03956 | 5/20 | 0.79 |
| ▸ | MMP2 | P08253 | 5/20 | 0.79 |
| ▸ | MMP9 | P14780 | 5/20 | 0.79 |
| ▸ | NPC1 | O15118 | 5/20 | 0.72 |
| ▸ | RAB9A | P51151 | 4/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.72 |
| ▸ | LMNA | P02545 | 3/20 | 0.72 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29388461 | 1.00 | KMT2A (1.00) | KMT2AMAPTMEN1TP53TRPV1 | |
| SCHEMBL1595342 | 1.00 | KMT2A (1.00) | KMT2AMAPTMEN1TP53TRPV1 | |
| SCHEMBL247433 | 0.88 | MMP1 (1.00) | KMT2AMAPTMEN1TP53TRPV1 | |
| SCHEMBL30080242 | 0.88 | MMP1 (1.00) | KMT2AMAPTMEN1TP53TRPV1 | |
| SCHEMBL247434 | 0.88 | MMP1 (1.00) | KMT2AMAPTMEN1TP53TRPV1 | |
| SCHEMBL247432 | 0.88 | MMP1 (1.00) | KMT2AMAPTMEN1TP53TRPV1 | |
| SCHEMBL5793760 | 0.87 | ALDH1A1 (0.77) | KMT2AMAPTMEN1TP53TRPV1 | |
| SCHEMBL13675628 | 0.85 | TRPV1 (1.00) | KMT2AMAPTMEN1TP53TRPV1 | |
| SCHEMBL21625686 | 0.84 | MAPT (1.00) | KMT2AMAPTMEN1TP53TRPV1 | |
| SCHEMBL26458454 | 0.83 | MMP1 (0.78) | KMT2AMAPTMEN1TP53TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 111 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12403139-B2 | Methods and compositions for prevention and treatment of cardiac hypertrophy | UNIVERSITY OF HAWAII (US) | 2025-09-02 | — | — | US | claimed |
| US-20240189303-A1 | METHODS AND COMPOSITIONS FOR PREVENTION AND TREATMENT OF CARDIAC HYPERTROPHY | UNIVERSITY OF HAWAII | 2024-06-13 | — | — | US | claimed |
| EP-3393462-B1 | COMPOSITIONS AND METHODS FOR TREATMENT, AMELIORATION, AND PREVENTION OF ANESTHESIA-INDUCED HYPOTHERMIA | UNIV ARIZONA (US) | 2023-02-01 | — | — | EP | claimed |
| US-20210069184-A1 | METHODS AND COMPOSITIONS FOR PREVENTION AND TREATMENT OF CARDIAC HYPERTROPHY | UNIV HAWAII (US) | 2021-03-11 | — | — | US | claimed |
| US-20190192508-A1 | METHODS AND COMPOSITIONS FOR PREVENTION AND TREATMENT OF CARDIAC HYPERTROPHY | UNIV HAWAII (US) | 2019-06-27 | — | — | US | claimed |
| US-20190008865-A1 | COMPOSITIONS AND METHODS FOR TREATMENT, AMELIORATION, AND PREVENTION OF ANESTHESIA-INDUCED HYPOTHERMIA | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA | 2019-01-10 | — | — | US | claimed |
| US-10137123-B2 | Methods and compositions for prevention and treatment of cardiac hypertrophy | UNIVERSITY OF HAWAII (US) | 2018-11-27 | — | — | US | claimed |
| EP-3393462-A1 | COMPOSITIONS AND METHODS FOR TREATMENT, AMELIORATION, AND PREVENTION OF ANESTHESIA-INDUCED HYPOTHERMIA | Arizona Board of Regents on behalf of the University of Arizona (US) | 2018-10-31 | — | — | EP | claimed |
| US-20170231982-A1 | METHODS AND COMPOSITIONS FOR PREVENTION AND TREATMENT OF CARDIAC HYPERTROPHY | UNIVERSITY OF HAWAII | 2017-08-17 | — | — | US | claimed |
| US-20170216459-A1 | COMPOSTIONS AND METHODS FOR DIAGNOSIS OF AXIAL PAIN WITH OR WITHOUT RADICULOPATHY | WARSAW ORTHOPEDIC INC (US) | 2017-08-03 | — | — | US | claimed |
| EP-2185150-A1 | USE OF TRANILAST AND DERIVATIVES THEREOF FOR THE THERAPY OF NEUROLOGICAL CONDITIONS | Sygnis Bioscience GmbH & Co. KG (DE) | 2010-05-19 | — | — | EP | claimed |
| EP-2030617-A1 | Use of tranilast and derivatives thereof for the therapy of neurological conditions | Sygnis Bioscience GmbH & Co. KG (DE) | 2009-03-04 | — | — | EP | claimed |
| WO-2009024543-A1 | USE OF TRANILAST AND DERIVATIVES THEREOF FOR THE THERAPY OF NEUROLOGICAL CONDITIONS | SYGNIS BIOSCIENCE GMBH & CO. KG (DE) | 2009-02-26 | — | — | WO | claimed |
| US-20080097229-A1 | Hygroscopic treatment for degenerating discs | WARSAW ORTHOPEDIC, INC. | 2008-04-24 | — | — | US | claimed |
| WO-2008027797-A2 | HYGROSCOPIC TREATMENT FOR DEGENERATING DISCS | WARSAW ORTHOPEDIC, INC (US) | 2008-03-06 | — | — | WO | claimed |
| US-20080008988-A1 | Compositions and methods for diagnosis of axial pain with or without radiculopathy | MEDTRONIC, INC. | 2008-01-10 | — | — | US | claimed |
| US-20070298407-A1 | Diagnostic kits and methods for diagnosis of axial pain with or without radiculopathy | MEDTRONIC, INC. | 2007-12-27 | — | — | US | claimed |
| US-20070293428-A1 | Methods of treating joint pain in a subject by using an anti-angiogenic agent | ZANELLA JOHN M | 2007-12-20 | — | — | US | claimed |
| US-20070253928-A1 | Pharmaceutical removal of neuronal extensions from a degenerating disc | WARSAW ORTHOPEDIC, INC. | 2007-11-01 | — | — | US | claimed |
| US-20070253930-A1 | Pharmaceutical removal of vascular and/or neuronal extensions form a degenerating disc | WARSAW ORTHOPEDIC, INC. | 2007-11-01 | — | — | US | claimed |