Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.33 |
| ▸ | CHRNG | P07510 | 1/20 | 0.33 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | CHRND | Q07001 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29604773 | 1.00 | HSD11B1 (0.33) | HSD11B1P2RX7CHRNA1CHRNGCHRNB1 | |
| SCHEMBL26969531 | 1.00 | HSD11B1 (0.33) | HSD11B1P2RX7CHRNA1CHRNGCHRNB1 | |
| SCHEMBL26969399 | 0.80 | LIPG (0.35) | OPRM1OPRD1OPRK1 | |
| SCHEMBL27121386 | 0.80 | LIPG (0.35) | OPRM1OPRD1OPRK1 | |
| SCHEMBL29604635 | 0.80 | LIPG (0.35) | OPRM1OPRD1OPRK1 | |
| SCHEMBL29604777 | 0.76 | GRIN1 (0.43) | HSD11B1CHRNA1CHRNGCHRNB1CHRNB2 | |
| SCHEMBL26644185 | 0.76 | GRIN1 (0.43) | HSD11B1CHRNA1CHRNGCHRNB1CHRNB2 | |
| SCHEMBL29604803 | 0.76 | GRIN1 (0.43) | HSD11B1CHRNA1CHRNGCHRNB1CHRNB2 | |
| SCHEMBL26644188 | 0.76 | GRIN1 (0.43) | HSD11B1CHRNA1CHRNGCHRNB1CHRNB2 | |
| SCHEMBL29604868 | 0.71 | GRIN1 (0.47) | HSD11B1CHRNA1CHRNGCHRNB1CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4244224-A1 | SMALL MOLECULE INHIBITORS OF NF-KB INDUCING KINASE | JANSSEN Pharmaceutica NV (BE) | 2023-09-20 | — | — | EP | disclosed |
| WO-2022104348-A1 | SMALL MOLECULE INHIBITORS OF NF-KB INDUCING KINASE | JANSSEN PHARMACEUTICA NV (BE) | 2022-05-19 | — | — | WO | disclosed |