Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.35 |
| ▸ | LPL | P06858 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 5/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.32 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | F2 | P00734 | 2/20 | 0.31 |
| ▸ | F11 | P03951 | 2/20 | 0.31 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.31 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.31 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27121386 | 1.00 | LIPG (0.35) | LIPGLPLROCK1BACE1PRMT5 | |
| SCHEMBL26969399 | 1.00 | LIPG (0.35) | LIPGLPLROCK1BACE1PRMT5 | |
| SCHEMBL29605611 | 0.81 | GRIN1 (0.38) | LIPGLPLROCK1BACE1OPRD1 | |
| SCHEMBL26644198 | 0.81 | GRIN1 (0.38) | LIPGLPLROCK1BACE1OPRD1 | |
| SCHEMBL26644195 | 0.81 | GRIN1 (0.38) | LIPGLPLROCK1BACE1OPRD1 | |
| SCHEMBL26969531 | 0.80 | HSD11B1 (0.33) | OPRM1OPRD1OPRK1 | |
| SCHEMBL29604688 | 0.80 | HSD11B1 (0.33) | OPRM1OPRD1OPRK1 | |
| SCHEMBL29604773 | 0.80 | HSD11B1 (0.33) | OPRM1OPRD1OPRK1 | |
| SCHEMBL29604602 | 0.77 | GRIN1 (0.41) | LIPGLPLROCK1BACE1OPRD1 | |
| SCHEMBL26969389 | 0.77 | GRIN1 (0.41) | LIPGLPLROCK1BACE1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4244224-A1 | SMALL MOLECULE INHIBITORS OF NF-KB INDUCING KINASE | JANSSEN Pharmaceutica NV (BE) | 2023-09-20 | — | — | EP | disclosed |
| WO-2022104348-A1 | SMALL MOLECULE INHIBITORS OF NF-KB INDUCING KINASE | JANSSEN PHARMACEUTICA NV (BE) | 2022-05-19 | — | — | WO | disclosed |