Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 1/20 | 0.52 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.52 |
| ▸ | AR | P10275 | 7/20 | 0.46 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2371380 | 1.00 | CRHBP (0.52) | CRHBPCRHR2ARSCN2AALDH1A1 | |
| SCHEMBL16636571 | 0.79 | ALDH1A1 (0.62) | CRHBPCRHR2ARSCN2AALDH1A1 | |
| SCHEMBL16637237 | 0.76 | CRHBP (0.49) | CRHBPCRHR2ARSCN2AALDH1A1 | |
| SCHEMBL24007294 | 0.76 | CRHBP (0.49) | CRHBPCRHR2ARSCN2AALDH1A1 | |
| SCHEMBL29604734 | 0.70 | AR (0.47) | CRHBPCRHR2ARSCN2AALDH1A1 | |
| SCHEMBL30486192 | 0.68 | HSD17B10 (0.73) | ARSCN2AALDH1A1HTTHSD17B10 | |
| SCHEMBL29204149 | 0.68 | HSD17B10 (0.73) | ARSCN2AALDH1A1HTTHSD17B10 | |
| SCHEMBL30905068 | 0.67 | KDM4E (0.56) | CRHBPCRHR2ARSCN2AALDH1A1 | |
| SCHEMBL14011323 | 0.67 | SCN2A (0.62) | CRHBPCRHR2ARSCN2AALDH1A1 | |
| SCHEMBL24195812 | 0.66 | HTT (0.49) | ARSCN2AALDH1A1HTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4244224-A1 | SMALL MOLECULE INHIBITORS OF NF-KB INDUCING KINASE | JANSSEN Pharmaceutica NV (BE) | 2023-09-20 | — | — | EP | disclosed |
| WO-2022104348-A1 | SMALL MOLECULE INHIBITORS OF NF-KB INDUCING KINASE | JANSSEN PHARMACEUTICA NV (BE) | 2022-05-19 | — | — | WO | disclosed |