Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | TYR | P14679 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 6/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 6/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.46 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.39 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | CDC42 | P60953 | 1/20 | 0.39 |
| ▸ | RAC1 | P63000 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22313388 | 0.84 | ABCB11 (0.50) | BCHETYRACHEAKR1C3AKR1C2 | |
| SCHEMBL28957756 | 0.83 | TYR (0.59) | BCHETYRACHEADRA2AADRA1A | |
| SCHEMBL16504443 | 0.83 | ADRA2A (0.51) | BCHETYRACHEADRA2AADRA1A | |
| SCHEMBL22214036 | 0.80 | CYP1A2 (0.52) | AKR1C3AKR1C2PTGS1ABCB11CYP1A2 | |
| SCHEMBL2975910 | 0.80 | CYP1A2 (0.52) | AKR1C3AKR1C2PTGS1ABCB11CYP1A2 | |
| SCHEMBL22313717 | 0.80 | ABCB11 (0.49) | BCHETYRACHEAKR1C3AKR1C2 | |
| SCHEMBL22393854 | 0.78 | ABCB11 (0.45) | BCHETYRACHEAKR1C3AKR1C2 | |
| SCHEMBL15086617 | 0.77 | CYP1A2 (0.60) | TYRAKR1C3AKR1C2PTGS1ABCB11 | |
| SCHEMBL10382340 | 0.77 | AKR1C3 (0.62) | AKR1C3AKR1C2PTGS1AKR1C1ABCB11 | |
| SCHEMBL15087422 | 0.77 | AKR1C3 (0.62) | AKR1C3AKR1C2PTGS1AKR1C1ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7776872-B2 | Diaminopyrimidines as P2X3 and P2X2/3 modulators | ROCHE PALO ALTO LLC (US) | 2010-08-17 | — | — | US | disclosed |
| US-20070049610-A1 | Diaminopyrimidines as P2X3 and P2X2/3 modulators | ROCHE PALO ALTO LLC | 2007-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070049610-A1 | Diaminopyrimidines as P2X3 and P2X2/3 modulators | P2RX3, P2RX6, P2RX2 | BCHE 3997/4885TYR 1377/4885ACHE 3357/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.