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SCHEMBL29610818

SCHEMBL29610818

COc1ccc(CNc2ncnc3c2c(Br)cn3[C@@H]2O[C@H](C(=O)NC3CCN(C)CC3)[C@H]3OC(C)(C)O[C@H]32)c(OC)c1

nearest known ligand 0.40

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ ADORA3 P0DMS8 4/20 0.40
▸ METTL3 Q86U44 9/20 0.39
▸ PRMT5 O14744 8/20 0.39
▸ WDR77 Q9BQA1 8/20 0.39
▸ METTL14 Q9HCE5 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24313535 1.00 ADORA3 (0.40) ADORA3METTL3PRMT5WDR77METTL14
SCHEMBL24314225 0.91 ADORA3 (0.38) ADORA3METTL3PRMT5WDR77
SCHEMBL29610924 0.91 ADORA3 (0.38) ADORA3METTL3PRMT5WDR77
SCHEMBL29611642 0.91 METTL3 (0.49) ADORA3METTL3PRMT5WDR77METTL14
SCHEMBL24313846 0.91 METTL3 (0.49) ADORA3METTL3PRMT5WDR77METTL14
SCHEMBL24313688 0.89 METTL3 (0.52) ADORA3METTL3PRMT5WDR77METTL14
SCHEMBL29611650 0.89 METTL3 (0.52) ADORA3METTL3PRMT5WDR77METTL14
SCHEMBL29611556 0.89 PRMT5 (0.38) ADORA3METTL3PRMT5WDR77
SCHEMBL24314273 0.89 PRMT5 (0.38) ADORA3METTL3PRMT5WDR77
SCHEMBL24313841 0.88 METTL3 (0.40) ADORA3METTL3PRMT5WDR77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4229067-A1 METTL3 MODULATORS Accent Therapeutics, Inc. (US) 2023-08-23 — — EP disclosed
WO-2022081739-A1 METTL3 MODULATORS ACCENT THERAPEUTICS, INC. (US) 2022-04-21 — — WO disclosed
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