Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 4/20 | 0.53 |
| ▸ | DPP4 | P27487 | 4/20 | 0.53 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.48 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13200852 | 0.92 | HTR3A (0.61) | HTR3ADPP4SOS1PIM1KDM4E | |
| Trifluoroacetic Acid SCHEMBL2966289 | 0.85 | HTR3A (0.54) | HTR3ADPP4SOS1PIM1 | |
| Trifluoroacetic Acid SCHEMBL2965269 | 0.83 | DPP4 (0.55) | HTR3ADPP4SOS1PIM1 | |
| Trifluoroacetic Acid SCHEMBL2965733 | 0.83 | HTR3A (0.51) | HTR3ADPP4SOS1PIM1KDM4E | |
| Trifluoroacetic Acid SCHEMBL2961372 | 0.83 | DPP4 (0.49) | DPP4 | |
| SCHEMBL27623275 | 0.83 | ALDH1A1 (0.47) | HTR3ADPP4KDM4ECYP1A2CYP2C9 | |
| Trifluoroacetic Acid SCHEMBL2962532 | 0.81 | HTR3A (0.51) | HTR3ADPP4SOS1PIM1CYP1A2 | |
| Trifluoroacetic Acid SCHEMBL2963765 | 0.81 | DPP4 (0.50) | HTR3ADPP4SOS1PIM1 | |
| Trifluoroacetic Acid SCHEMBL2952470 | 0.80 | DPP4 (0.52) | HTR3ADPP4SOS1PIM1 | |
| Trifluoroacetic Acid SCHEMBL2968179 | 0.80 | DPP4 (0.50) | HTR3ADPP4SOS1PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7772226-B2 | Condensed imidazole derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-08-10 | — | — | US | disclosed |
| US-20090018331-A1 | CONDENSED IMIDAZOLE DERIVATIVES | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-01-15 | — | — | US | disclosed |
| US-20070219178-A1 | PREVENTIVE OR THERAPEUTIC AGENTS FOR MULTIPLE SCLEROSIS | EISAI CO., LTD. (JP) | 2007-09-20 | — | — | US | disclosed |
| US-20060100199-A1 | Novel condensed imidazole derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2006-05-11 | — | — | US | disclosed |
| US-20060094722-A1 | Combination drug | EISAI CO., LTD. (JP) | 2006-05-04 | — | — | US | disclosed |
| US-20060063787-A1 | Condensed imidazole derivatives | EISAI CO., LTD. (JP) | 2006-03-23 | — | — | US | disclosed |
| EP-1557165-A1 | COMBINATION DRUG | Eisai Co., Ltd. (JP) | 2005-07-27 | — | — | EP | disclosed |
| EP-1514552-A1 | NOVEL FUSED IMIDAZOLE DERIVATIVE | Eisai Co., Ltd. (JP) | 2005-03-16 | — | — | EP | disclosed |
| US-20040116328-A1 | Condensed imidazole derivatives | EISAI CO., LTD. (JP) | 2004-06-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070219178-A1 | PREVENTIVE OR THERAPEUTIC AGENTS FOR MULTIPLE SCLEROSIS | MYT1, AQP4, AQP1 | HTR3A 3951/4885DPP4 2329/4885SOS1 2401/4885 |
| US-20060100199-A1 | Novel condensed imidazole derivatives | H1-2, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, H1-4 | HTR3A 2063/4885DPP4 4422/4885SOS1 3113/4885 |
| US-20060094722-A1 | Combination drug | DPP4, GLP1R, DPP7 | HTR3A 2401/4885DPP4 1/4885SOS1 3340/4885 |
| US-20060063787-A1 | Condensed imidazole derivatives | DPP4, HDAC1, DPP7 | HTR3A 1879/4885DPP4 1/4885SOS1 2653/4885 |
| US-20090018331-A1 | CONDENSED IMIDAZOLE DERIVATIVES | DPP4, HDAC1, DPP7 | HTR3A 1879/4885DPP4 1/4885SOS1 2653/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.