Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 3/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL29612304 | 0.83 | GABRA1 (0.34) | GABRA1GABRB2KDM4EMEN1MAPT | |
| Hydrochloric Acid SCHEMBL7144896 | 0.83 | GABRA1 (0.34) | GABRA1GABRB2KDM4EMEN1MAPT | |
| Hydrochloric Acid SCHEMBL6525777 | 0.81 | — | — | |
| Fluoride Ion SCHEMBL7638699 | 0.80 | — | — | |
| Fluoride Ion SCHEMBL7638711 | 0.80 | GABRA1 (0.34) | GABRA1GABRB2KDM4EMEN1MAPT | |
| Hydrochloric Acid SCHEMBL27479364 | 0.78 | PDCD1 (0.32) | — | |
| Hydrochloric Acid SCHEMBL28407108 | 0.78 | GABRA1 (0.35) | GABRA1GABRB2KDM4EMEN1MAPT | |
| Hydrochloric Acid SCHEMBL7599684 | 0.78 | GABRA1 (0.35) | GABRA1GABRB2KDM4EMEN1MAPT | |
| Hydrochloric Acid SCHEMBL3918950 | 0.76 | KDM4E (0.40) | KDM4ETDP1 | |
| Hydrochloric Acid SCHEMBL29612340 | 0.76 | EDNRB (0.35) | TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2915824-B1 | METALLOCENE LIGANDS, METALLOCENE COMPOUNDS AND METALLOCENE CATALYSTS, THEIR SYNTHESIS AND THEIR USE FOR THE POLYMERIZATION OF OLEFINS | LUMMUS NOVOLEN TECHNOLOGY GMBH (DE) | 2022-05-25 | — | — | EP | claimed |
| EP-2915824-B1 | METALLOCENE LIGANDS, METALLOCENE COMPOUNDS AND METALLOCENE CATALYSTS, THEIR SYNTHESIS AND THEIR USE FOR THE POLYMERIZATION OF OLEFINS | LUMMUS NOVOLEN TECHNOLOGY GMBH (DE) | 2022-05-25 | — | — | EP | disclosed |