Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 3/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL29612304 | 1.00 | GABRA1 (0.34) | GABRA1GABRB2TSHRKDM4EMEN1 | |
| Fluoride Ion SCHEMBL7638711 | 0.97 | GABRA1 (0.34) | GABRA1GABRB2TSHRKDM4EMEN1 | |
| Hydrochloric Acid SCHEMBL29612334 | 0.83 | GABRA1 (0.34) | GABRA1GABRB2KDM4EMEN1MAPT | |
| Hydrochloric Acid SCHEMBL6518917 | 0.81 | — | — | |
| Hydrochloric Acid SCHEMBL27509773 | 0.79 | CYP1A2 (0.30) | — | |
| Hydrochloric Acid SCHEMBL6910241 | 0.78 | GABRA1 (0.35) | GABRA1GABRB2TSHRKDM4EMEN1 | |
| Hydrochloric Acid SCHEMBL29565874 | 0.78 | GABRA1 (0.39) | GABRA1GABRB2TSHRKDM4EMEN1 | |
| Hydrochloric Acid SCHEMBL7811941 | 0.78 | GABRA1 (0.39) | GABRA1GABRB2TSHRKDM4EMEN1 | |
| Hydrochloric Acid SCHEMBL29612648 | 0.76 | EDNRB (0.35) | — | |
| Hydrochloric Acid SCHEMBL6901169 | 0.76 | CHRM2 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1311593-A2 | POLYPROPYLENE FILMS | Exxonmobil Chemical Patents Inc. (US) | 2003-05-21 | — | — | EP | disclosed |
| WO-2002070570-A2 | PROPYLENE POLYMERS FOR FILMS | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2002-09-12 | — | — | WO | disclosed |
| WO-2002016480-A2 | POLYPROPYLENE FILMS | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2002-02-28 | — | — | WO | disclosed |