SCHEMBL29612474

SCHEMBL29612474

O=[N+]([O-])c1cc(Cl)c(Oc2ccc3nc(C4CC4)ccc3c2)c(Cl)c1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 1/20 0.39
HDAC8 Q9BY41 1/20 0.39
HDAC6 Q9UBN7 1/20 0.39
KDM4E B2RXH2 1/20 0.37
PIK3C3 Q8NEB9 1/20 0.36
PDE7A Q13946 1/20 0.35
MEN1 O00255 3/20 0.35
KMT2A Q03164 3/20 0.35
PIN1 Q13526 1/20 0.34
ALDH1A1 P00352 6/20 0.34
CYP2C9 P11712 2/20 0.33
CYP3A4 P08684 3/20 0.33
PPARG P37231 2/20 0.33
CYP2C19 P33261 2/20 0.33
HTR3E A5X5Y0 1/20 0.33
HTR3B O95264 1/20 0.33
CYP1A2 P05177 1/20 0.33
SLC6A4 P31645 1/20 0.33
THPO P40225 1/20 0.33
HTR3A P46098 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23042369 1.00 HDAC1 (0.39) HDAC1HDAC8HDAC6KDM4EPIK3C3
SCHEMBL23042410 0.83 HDAC1 (0.43) HDAC1HDAC8HDAC6KDM4EPDE7A
SCHEMBL29612543 0.83 HDAC1 (0.43) HDAC1HDAC8HDAC6KDM4EPDE7A
SCHEMBL23062649 0.82 NCF1 (0.35) CYP3A4PPARGMAPTKCNH2HRH3
SCHEMBL29612747 0.82 NCF1 (0.35) CYP3A4PPARGMAPTKCNH2HRH3
SCHEMBL23063352 0.82 HRH3 (0.36) ALDH1A1CYP3A4PPARGKCNH2HRH3
SCHEMBL29526933 0.81 MEN1 (0.39) PIK3C3PDE7AMEN1KMT2AALDH1A1
SCHEMBL23042415 0.81 HTT (0.43) HDAC1HDAC8HDAC6KDM4EPDE7A
SCHEMBL31458446 0.77 ALDH1A1 (0.50) ALDH1A1CYP3A4CYP2C19HTR3EHTR3B
SCHEMBL29612551 0.76 PPARG (0.53) KDM4EMEN1KMT2APIN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114430743-A Thyroid hormone receptor beta agonist compounds 拓臻制药公司 2022-05-03 CN disclosed