Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 15/20 | 0.45 |
| ▸ | DRD3 | P35462 | 3/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18322295 | 1.00 | PDE4A (0.45) | PDE4ADRD3KCNH2 | |
| SCHEMBL30489158 | 0.77 | PDE4A (0.52) | PDE4A | |
| SCHEMBL18330320 | 0.77 | PDE4A (0.52) | PDE4A | |
| SCHEMBL10289862 | 0.76 | CYP2D6 (0.49) | DRD3KCNH2 | |
| SCHEMBL10255031 | 0.73 | HRH3 (0.55) | DRD3KCNH2 | |
| SCHEMBL13711919 | 0.73 | DRD3 (0.51) | DRD3KCNH2 | |
| SCHEMBL29030298 | 0.72 | HTR2A (0.33) | DRD3KCNH2 | |
| SCHEMBL30489145 | 0.72 | HTR2A (0.33) | DRD3KCNH2 | |
| Hydrochloric Acid SCHEMBL7402572 | 0.71 | HTR3A (0.44) | — | |
| SCHEMBL9259549 | 0.70 | HTR2A (0.44) | DRD3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107787322-B | Tricyclic compounds and their use as phosphodiesterase inhibitors | 辉瑞大药厂 | 2023-07-07 | — | — | CN | disclosed |
| EP-3766885-B1 | TRICYCLIC COMPOUNDS AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | PFIZER (US) | 2022-05-25 | — | — | EP | disclosed |