Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.33 |
| ▸ | HTR2C | P28335 | 3/20 | 0.33 |
| ▸ | DRD3 | P35462 | 4/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29030298 | 1.00 | HTR2A (0.33) | HTR2AHTR2CDRD3NOTUMKCNH2 | |
| SCHEMBL29612960 | 0.72 | PDE4A (0.45) | DRD3KCNH2 | |
| SCHEMBL18322295 | 0.72 | PDE4A (0.45) | DRD3KCNH2 | |
| SCHEMBL30882129 | 0.64 | NOTUM (0.40) | HTR2AHTR2CDRD3NOTUMHTR1A | |
| SCHEMBL28345272 | 0.64 | NOTUM (0.40) | HTR2AHTR2CDRD3NOTUMHTR1A | |
| SCHEMBL10289862 | 0.64 | CYP2D6 (0.49) | HTR2AHTR2CDRD3KCNH2HTR1A | |
| SCHEMBL4751694 | 0.64 | HRH3 (0.52) | HTR2AHTR2CKMT2A | |
| SCHEMBL13711919 | 0.64 | DRD3 (0.51) | HTR2AHTR2CDRD3KCNH2HTR1A | |
| SCHEMBL7396812 | 0.63 | RPS6KA3 (0.43) | HTR2AHTR2CNOTUMKMT2A | |
| SCHEMBL20777930 | 0.63 | NOTUM (0.39) | HTR2AHTR2CDRD3NOTUMKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107787322-B | Tricyclic compounds and their use as phosphodiesterase inhibitors | 辉瑞大药厂 | 2023-07-07 | — | — | CN | disclosed |