Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.45 |
| ▸ | GCGR | P47871 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GSR | P00390 | 1/20 | 0.42 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.42 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.42 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13199237 | 0.84 | ALDH1A1 (0.61) | ALDH1A1MAPTTP53KDM4EMEN1 | |
| SCHEMBL13199158 | 0.83 | ALDH1A1 (0.58) | ALDH1A1MAPTTP53KDM4EMEN1 | |
| SCHEMBL13199173 | 0.81 | ALDH1A1 (0.54) | ALDH1A1MAPTTP53KDM4EGSR | |
| SCHEMBL2954979 | 0.81 | ALDH1A1 (0.46) | ALDH1A1MAPTTP53GCGRKDM4E | |
| SCHEMBL13199229 | 0.81 | ALDH1A1 (0.62) | ALDH1A1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL13199129 | 0.80 | ALDH1A1 (0.57) | ALDH1A1MAPTTP53KDM4EMEN1 | |
| SCHEMBL13199261 | 0.80 | CA2 (0.50) | ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL13199258 | 0.80 | ALDH1A1 (0.48) | ALDH1A1MAPTTP53KDM4EMEN1 | |
| SCHEMBL13199110 | 0.79 | KDM4E (0.55) | ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL14098308 | 0.78 | ALDH1A1 (0.43) | ALDH1A1MAPTTP53KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767716-B2 | Acyl hydrazines as kinase inhibitors, in particular for SGK | MERCK PATENT GMBH (DE) | 2010-08-03 | — | — | US | disclosed |
| US-7767716-B2 | Acyl hydrazines as kinase inhibitors, in particular for SGK | MERCK PATENT GMBH (DE) | 2010-08-03 | — | — | US | disclosed |
| US-20080167380-A1 | Acyl Hydrazines as Kinase Inhibitors, in Particular for Sgk | MERCK PATENT GMBH (DE) | 2008-07-10 | — | — | US | disclosed |
| US-20080167380-A1 | Acyl Hydrazines as Kinase Inhibitors, in Particular for Sgk | MERCK PATENT GMBH (DE) | 2008-07-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080167380-A1 | Acyl Hydrazines as Kinase Inhibitors, in Particular for Sgk | SGK1, AGK, SGK2 | ALDH1A1 1664/4885MAPT 4448/4885TP53 4760/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.