Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK7 | P50613 | 15/20 | 0.57 |
| ▸ | CCNH | P51946 | 13/20 | 0.57 |
| ▸ | CDK13 | Q14004 | 2/20 | 0.48 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.48 |
| ▸ | CDK1 | P06493 | 2/20 | 0.48 |
| ▸ | CDK2 | P24941 | 2/20 | 0.48 |
| ▸ | CDK9 | P50750 | 2/20 | 0.48 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.48 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.48 |
| ▸ | CCNK | O75909 | 1/20 | 0.48 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.48 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.48 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.48 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 3/20 | 0.44 |
| ▸ | CDK8 | P49336 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29129122 | 1.00 | CDK7 (0.57) | CDK7CCNHCDK13CDK12CDK1 | |
| SCHEMBL15647663 | 0.90 | CDK7 (0.48) | CDK7CCNHCDK13CDK12CDK1 | |
| SCHEMBL15648388 | 0.89 | CDK7 (0.44) | CDK7CCNHCDK13CDK12CDK1 | |
| SCHEMBL15648037 | 0.88 | CDK7 (0.43) | CDK7CCNHCDK13CDK12CDK1 | |
| SCHEMBL15649053 | 0.87 | CDK7 (0.55) | CDK7CCNHCDK13CDK12CDK1 | |
| SCHEMBL29613463 | 0.87 | CDK7 (0.55) | CDK7CCNHCDK13CDK12CDK1 | |
| SCHEMBL16655025 | 0.87 | MET (0.51) | CDK7CCNHEGFRHTR6 | |
| SCHEMBL16655391 | 0.86 | ABL1 (0.48) | CDK7CCNHEGFRHTR6 | |
| SCHEMBL24510839 | 0.85 | CDK7 (0.67) | CDK7CCNHCDK13CDK12CDK1 | |
| SCHEMBL19054637 | 0.85 | HTR6 (0.43) | CDK7CCNHCDK1CDK2CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4259133-A1 | METHODS AND COMPOUNDS FOR MODULATING MYOTONIC DYSTROPHY 1 | Design Therapeutics, Inc. (US) | 2023-10-18 | — | — | EP | disclosed |
| WO-2022126000-A1 | METHODS AND COMPOUNDS FOR MODULATING MYOTONIC DYSTROPHY 1 | Design Therapeutics, Inc. (US) | 2022-06-16 | — | — | WO | disclosed |