Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK7 | P50613 | 10/20 | 0.55 |
| ▸ | CCNH | P51946 | 8/20 | 0.55 |
| ▸ | CDK1 | P06493 | 3/20 | 0.46 |
| ▸ | CDK2 | P24941 | 3/20 | 0.46 |
| ▸ | CDK9 | P50750 | 3/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.46 |
| ▸ | CDK13 | Q14004 | 2/20 | 0.46 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.46 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.46 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.46 |
| ▸ | CCNK | O75909 | 1/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.46 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 4/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15649053 | 1.00 | CDK7 (0.55) | CDK7CCNHCDK1CDK2CDK9 | |
| SCHEMBL17141301 | 0.93 | CDK7 (0.52) | CDK7CCNHCDK1CDK2CDK9 | |
| SCHEMBL17141040 | 0.92 | CDK7 (0.48) | CDK7CCNHCDK1CDK2CDK9 | |
| SCHEMBL17022831 | 0.89 | CDK7 (0.47) | CDK7CCNHEGFRJAK1HDAC1 | |
| SCHEMBL15648499 | 0.89 | CDK5 (0.47) | CDK7CCNHCDK1CDK2CDK9 | |
| SCHEMBL15648076 | 0.88 | HTR6 (0.44) | CDK7CCNHHTR6DRD2HTR2A | |
| SCHEMBL29129122 | 0.87 | CDK7 (0.57) | CDK7CCNHCDK1CDK2CDK9 | |
| SCHEMBL29613456 | 0.87 | CDK7 (0.57) | CDK7CCNHCDK1CDK2CDK9 | |
| SCHEMBL16665592 | 0.87 | EGFR (0.51) | CDK7CCNHCDK1CDK2CDK9 | |
| SCHEMBL29613438 | 0.87 | EGFR (0.51) | CDK7CCNHCDK1CDK2CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4259133-A1 | METHODS AND COMPOUNDS FOR MODULATING MYOTONIC DYSTROPHY 1 | Design Therapeutics, Inc. (US) | 2023-10-18 | — | — | EP | disclosed |
| WO-2022126000-A1 | METHODS AND COMPOUNDS FOR MODULATING MYOTONIC DYSTROPHY 1 | Design Therapeutics, Inc. (US) | 2022-06-16 | — | — | WO | disclosed |