Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.52 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.49 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.49 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.49 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15584613 | 0.91 | KCNJ1 (0.57) | MAPTCACNA1HCACNA1BCACNA1CKCNJ1 | |
| SCHEMBL30313258 | 0.83 | CACNA1H (0.54) | MAPTCACNA1HCACNA1BCACNA1CBRD4 | |
| SCHEMBL22775612 | 0.83 | MAPT (0.59) | MAPTKCNJ1KDM4EALDH1A1LMNA | |
| SCHEMBL29613729 | 0.82 | CACNA1H (0.53) | MAPTCACNA1HCACNA1BCACNA1CBRD4 | |
| SCHEMBL22013237 | 0.82 | CACNA1H (0.53) | CACNA1HCACNA1BCACNA1CL3MBTL1BCHE | |
| SCHEMBL4149629 | 0.82 | CACNA1H (0.53) | CACNA1HCACNA1BCACNA1CBRD4BCHE | |
| SCHEMBL22775707 | 0.82 | CACNA1H (0.53) | MAPTCACNA1HCACNA1BCACNA1CBRD4 | |
| SCHEMBL28289712 | 0.81 | KDM4E (0.51) | MAPTKCNJ1KDM4EALDH1A1LMNA | |
| SCHEMBL24507620 | 0.81 | CACNA1H (0.52) | MAPTCACNA1HCACNA1BCACNA1CKDM4E | |
| SCHEMBL38661238 | 0.81 | CACNA1H (0.52) | MAPTCACNA1HCACNA1BCACNA1CKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12552770-B2 | Compounds for treating respiratory disease | TMEM16A LIMITED (GB) | 2026-02-17 | — | — | US | disclosed |
| EP-3983389-A1 | COMPOUNDS FOR TREATING RESPIRATORY DISEASE | TMEM16A LIMITED (GB) | 2022-04-20 | — | — | EP | disclosed |
| US-20220098167-A1 | COMPOUNDS FOR TREATING RESPIRATORY DISEASE | TMEM16A LTD (GB) | 2022-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12552770-B2 | Compounds for treating respiratory disease | TMEM109, SCN1A, SLC16A1 | MAPT 1158/4885CACNA1H 109/4885CACNA1B 80/4885 |
| US-20220098167-A1 | COMPOUNDS FOR TREATING RESPIRATORY DISEASE | TMEM109, SLC16A1, CFTR | MAPT 1182/4885CACNA1H 237/4885CACNA1B 207/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.