Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.50 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | LAP3 | P28838 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.39 |
| ▸ | GMNN | O75496 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CETP | P11597 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | UBE2N | P61088 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL28119320 | 0.78 | OPRM1 (0.48) | OPRM1SPHK1TP53LAP3CYP2D6 | |
| SCHEMBL28087402 | 0.76 | OPRM1 (0.46) | OPRM1SPHK1TP53LAP3CYP2D6 | |
| SCHEMBL27890430 | 0.75 | OPRM1 (0.44) | OPRM1SPHK1TP53LAP3CYP2D6 | |
| Hydrogen Sulfide SCHEMBL6829644 | 0.73 | OPRM1 (0.60) | OPRM1SPHK1TP53LAP3CYP2D6 | |
| Hexane SCHEMBL16244743 | 0.69 | OPRM1 (0.63) | OPRM1SPHK1TP53LAP3CYP2D6 | |
| SCHEMBL615266 | 0.69 | OPRM1 (0.63) | OPRM1SPHK1TP53LAP3CYP2D6 | |
| SCHEMBL27976138 | 0.69 | OPRM1 (0.63) | OPRM1SPHK1TP53LAP3CYP2D6 | |
| SCHEMBL672857 | 0.69 | OPRM1 (0.63) | OPRM1SPHK1TP53LAP3CYP2D6 | |
| SCHEMBL29533 | 0.69 | — | — | |
| SCHEMBL24017129 | 0.67 | OPRM1 (0.60) | OPRM1SPHK1TP53LAP3CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8951499-B2 | Trifunctional reagent for conjugation to a biomolecule | UNIVERSITY OF WASHINGTON (US) | 2015-02-10 | — | — | US | disclosed |
| EP-1095274-B1 | TRIFUNCTIONAL REAGENT FOR CONJUGATION TO A BIOMOLECULE | DEPT OF RADIATION ONCOLOGY UNI (US) | 2010-09-29 | — | — | EP | disclosed |
| US-20070071673-A1 | Trifunctional reagent for conjugation to a biomolecule | MITRA MEDICAL TECHNOLOGY AB (SE) | 2007-03-29 | — | — | US | disclosed |
| US-20050271673-A1 | Trifunctional reagent for conjugation to a biomolecule | GLYCOREX TRANSPLANTATION AB (SE) | 2005-12-08 | — | — | US | disclosed |
| US-20010023288-A1 | Trifunctional reagent for conjugation to a biomolecule | GLYCOREX TRANSPLANTATION AB (SE) | 2001-09-20 | — | — | US | disclosed |
| EP-1095274-A1 | TRIFUNCTIONAL REAGENT FOR CONJUGATION TO A BIOMOLECULE | Department of Radiation Oncology, University of Washington (US) | 2001-05-02 | — | — | EP | disclosed |
| WO-2000002051-A1 | TRIFUNCTIONAL REAGENT FOR CONJUGATION TO A BIOMOLECULE | DEPT. OF RADIATION ONCOLOGY, UNIVERSITY OF WASHINGTON (US) | 2000-01-13 | — | — | WO | disclosed |
| WO-2000002050-A1 | TRIFUNCTIONAL REAGENT FOR CONJUGATION TO A BIOMOLECULE | DEPARTMENT OF RADIATION ONCOLOGY, UNIVERSITY OF WASHINGTON (US) | 2000-01-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070071673-A1 | Trifunctional reagent for conjugation to a biomolecule | UACA, TNFSF11, CD40 | OPRM1 2948/4885SPHK1 1965/4885TP53 800/4885 |
| US-20010023288-A1 | Trifunctional reagent for conjugation to a biomolecule | CD40, UACA, CD47 | OPRM1 3136/4885SPHK1 1717/4885TP53 979/4885 |
| US-20050271673-A1 | Trifunctional reagent for conjugation to a biomolecule | UACA, TNFRSF1A, TNFSF11 | OPRM1 2605/4885SPHK1 2318/4885TP53 544/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.