Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.48 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.45 |
| ▸ | DNM1 | Q05193 | 6/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.42 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.42 |
| ▸ | GMNN | O75496 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | THPO | P40225 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CETP | P11597 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | UBE2N | P61088 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propene SCHEMBL28832717 | 0.86 | OPRM1 (0.40) | OPRM1SPHK1DNM1CYP2D6TP53 | |
| Hydrochloric Acid SCHEMBL5583069 | 0.84 | FAAH (0.44) | SPHK1CYP2D6TP53CYP3A4LMNA | |
| SCHEMBL28087402 | 0.79 | OPRM1 (0.46) | OPRM1SPHK1CYP2D6TP53CYP3A4 | |
| SCHEMBL2961401 | 0.78 | OPRM1 (0.50) | OPRM1SPHK1CYP2D6TP53CYP3A4 | |
| SCHEMBL27890430 | 0.77 | OPRM1 (0.44) | OPRM1SPHK1DNM1CYP2D6TP53 | |
| Bromide SCHEMBL584403 | 0.75 | DNM1 (0.46) | OPRM1DNM1TP53CYP3A4LMNA | |
| Bromide SCHEMBL28545117 | 0.75 | DNM1 (0.46) | OPRM1DNM1TP53CYP3A4LMNA | |
| Bromide SCHEMBL594635 | 0.75 | DNM1 (0.46) | OPRM1DNM1TP53CYP3A4LMNA | |
| Bromide SCHEMBL21494331 | 0.75 | DNM1 (0.46) | OPRM1DNM1TP53CYP3A4LMNA | |
| Bromide SCHEMBL28730749 | 0.75 | DNM1 (0.46) | OPRM1DNM1TP53CYP3A4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106396093-A | Method for accelerating granulation of activated sludge | 成都信息工程大学 | 2017-02-15 | — | — | CN | claimed |
| CN-106396093-A | Method for accelerating granulation of activated sludge | 成都信息工程大学 | 2017-02-15 | — | — | CN | disclosed |