Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 2/20 | 0.46 |
| ▸ | PLK4 | O00444 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | LTK | P29376 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.46 |
| ▸ | PRKX | P51817 | 1/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.46 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.46 |
| ▸ | MST1R | Q04912 | 1/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.46 |
| ▸ | BTK | Q06187 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23198277 | 1.00 | MAP4K4 (0.46) | MAP4K4PLK4CHEK1AURKADAPK3 | |
| SCHEMBL29615084 | 0.79 | NOS1 (0.46) | MAP4K4PLK4CHEK1AURKADAPK3 | |
| SCHEMBL23198253 | 0.79 | NOS1 (0.46) | MAP4K4PLK4CHEK1AURKADAPK3 | |
| SCHEMBL3064844 | 0.77 | NOS1 (0.63) | MAP4K4PLK4CHEK1AURKADAPK3 | |
| SCHEMBL4752843 | 0.76 | NOS1 (0.53) | MAP4K4PLK4CHEK1AURKADAPK3 | |
| SCHEMBL23198266 | 0.76 | NOS1 (0.46) | MAP4K4PLK4CHEK1AURKADAPK3 | |
| SCHEMBL29614917 | 0.76 | NOS1 (0.46) | MAP4K4PLK4CHEK1AURKADAPK3 | |
| SCHEMBL23198231 | 0.75 | METAP2 (0.61) | MAP4K4AURKACSF1RKDRFLT3 | |
| SCHEMBL29614992 | 0.75 | METAP2 (0.61) | MAP4K4AURKACSF1RKDRFLT3 | |
| SCHEMBL23221345 | 0.75 | CDK5 (0.40) | MAP4K4PLK4CHEK1AURKADAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109803963-B | Cyano-substituted heterocycles having USP30 inhibitor activity | 特殊治疗有限公司 | 2022-04-26 | — | — | CN | disclosed |