Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 3/20 | 0.53 |
| ▸ | METAP2 | P50579 | 1/20 | 0.53 |
| ▸ | AKT1 | P31749 | 2/20 | 0.48 |
| ▸ | AKT2 | P31751 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.47 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.47 |
| ▸ | CSF1R | P07333 | 2/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.47 |
| ▸ | LTK | P29376 | 2/20 | 0.47 |
| ▸ | KDR | P35968 | 2/20 | 0.47 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.47 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.47 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3064844 | 0.86 | NOS1 (0.63) | NOS1METAP2FGFR1CDK5CLK4 | |
| SCHEMBL16835565 | 0.80 | NPC1 (0.45) | NOS1METAP2FGFR1ROCK1KDM4E | |
| SCHEMBL18188598 | 0.77 | AKT1 (0.44) | NOS1METAP2AKT1AKT2LMNA | |
| SCHEMBL29614980 | 0.76 | MAP4K4 (0.46) | NOS1FGFR1CDK5CLK4DYRK1B | |
| SCHEMBL30809709 | 0.76 | PLK4 (0.58) | NOS1METAP2FGFR1CDK5CLK4 | |
| SCHEMBL23198277 | 0.76 | MAP4K4 (0.46) | NOS1FGFR1CDK5CLK4DYRK1B | |
| SCHEMBL31134213 | 0.75 | LMNA (0.51) | METAP2AKT1AKT2LMNAFGFR1 | |
| SCHEMBL28151785 | 0.75 | METAP2 (0.58) | METAP2AKT1AKT2LMNAFGFR1 | |
| SCHEMBL23604050 | 0.75 | NOS1 (0.44) | NOS1FGFR1CDK5CLK4DYRK1B | |
| SCHEMBL31722116 | 0.74 | NOS1 (0.50) | NOS1FGFR1CDK5CLK4DYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1569911-B1 | INDAZOLE DERIVATIVES AS CRF ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2008-07-02 | — | — | EP | disclosed |