Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 4/20 | 0.55 |
| ▸ | NOS2 | P35228 | 4/20 | 0.55 |
| ▸ | NOS1 | P29475 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | GABRP | O00591 | 2/20 | 0.38 |
| ▸ | GABRD | O14764 | 2/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.38 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.38 |
| ▸ | GABRE | P78334 | 2/20 | 0.38 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22918783 | 1.00 | NOS3 (0.55) | NOS3NOS2NOS1KDM4EMEN1 | |
| SCHEMBL25877820 | 0.80 | DYRK1A (0.43) | NOS3NOS2NOS1DYRK1AAAK1 | |
| SCHEMBL16332680 | 0.79 | RECQL (0.42) | BRD4CCL2ADORA1AAK1PDE2A | |
| SCHEMBL30225256 | 0.79 | RECQL (0.42) | BRD4CCL2ADORA1AAK1PDE2A | |
| SCHEMBL16054187 | 0.79 | NOS3 (0.53) | NOS3NOS2NOS1KDM4EMEN1 | |
| SCHEMBL29860743 | 0.79 | NOS3 (0.53) | NOS3NOS2NOS1KDM4EMEN1 | |
| SCHEMBL27037888 | 0.76 | ALDH1A1 (0.53) | KDM4EMEN1KMT2AMAPK14BRD4 | |
| SCHEMBL30699070 | 0.76 | ALDH1A1 (0.53) | KDM4EMEN1KMT2AMAPK14BRD4 | |
| SCHEMBL31348007 | 0.76 | NOS3 (0.64) | NOS3NOS2NOS1KDM4EMEN1 | |
| SCHEMBL7499287 | 0.76 | NOS3 (0.64) | NOS3NOS2NOS1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118955500-A | 4- (Imidazo [1,2-a ] pyridin-3-yl) -pyrimidine derivatives | 默克专利股份公司 | 2024-11-15 | — | — | CN | disclosed |
| EP-4003992-A1 | 4-(IMIDAZO[1,2-A]PYRIDIN-3-YL) -PYRIMIDINE DERIVATIVES | Merck Patent GmbH (DE) | 2022-06-01 | — | — | EP | disclosed |
| CN-114174293-A | 4- (imidazo [1,2-a ] pyridin-3-yl) -pyrimidine derivatives | 默克专利股份公司 | 2022-03-11 | — | — | CN | disclosed |