Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.47 |
| ▸ | NOS3 | P29474 | 2/20 | 0.39 |
| ▸ | NOS1 | P29475 | 2/20 | 0.39 |
| ▸ | NOS2 | P35228 | 2/20 | 0.39 |
| ▸ | HRH2 | P25021 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22918689 | 1.00 | HRH3 (0.47) | HRH3SLC6A4NOS3NOS1NOS2 | |
| SCHEMBL29615499 | 0.94 | DRD2 (0.43) | HRH3SLC6A4NOS3NOS1NOS2 | |
| SCHEMBL22919100 | 0.94 | DRD2 (0.43) | HRH3SLC6A4NOS3NOS1NOS2 | |
| SCHEMBL22918759 | 0.80 | HRH3 (0.54) | HRH3EHMT2MAOB | |
| SCHEMBL29615450 | 0.80 | HRH3 (0.54) | HRH3EHMT2MAOB | |
| SCHEMBL22918755 | 0.78 | HRH3 (0.58) | HRH3NOS3NOS1NOS2 | |
| SCHEMBL29868643 | 0.77 | HRH3 (0.45) | HRH3SLC6A4HRH2HRH1DRD2 | |
| SCHEMBL29615558 | 0.76 | HRH3 (0.57) | HRH3HRH2HRH1FGFR1 | |
| SCHEMBL22918726 | 0.76 | HRH3 (0.57) | HRH3HRH2HRH1FGFR1 | |
| SCHEMBL22919001 | 0.73 | LTA4H (0.57) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4003992-A1 | 4-(IMIDAZO[1,2-A]PYRIDIN-3-YL) -PYRIMIDINE DERIVATIVES | Merck Patent GmbH (DE) | 2022-06-01 | — | — | EP | disclosed |
| CN-114174293-A | 4- (imidazo [1,2-a ] pyridin-3-yl) -pyrimidine derivatives | 默克专利股份公司 | 2022-03-11 | — | — | CN | disclosed |