Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 2/20 | 0.55 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.46 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.46 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.46 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.46 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.46 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.43 |
| ▸ | PARP1 | P09874 | 3/20 | 0.42 |
| ▸ | KCNMA1 | Q12791 | 5/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CCND1 | P24385 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23495851 | 1.00 | METAP2 (0.55) | METAP2GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL17536725 | 0.78 | PARP1 (0.59) | METAP2GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL30322789 | 0.77 | PARP1 (0.55) | METAP2GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL12396542 | 0.77 | PARP1 (0.55) | METAP2GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL7221840 | 0.71 | METAP2 (1.00) | METAP2GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL1009117 | 0.68 | PARP1 (0.67) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL29568550 | 0.68 | PARP1 (0.67) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL29601450 | 0.68 | PARP1 (0.67) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL15590643 | 0.68 | MAPT (0.56) | METAP2KDM4E | |
| SCHEMBL12590228 | 0.68 | GABRA1 (0.47) | METAP2GABRA1GABRG2GABRB3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12103929-B2 | Tricyclic compounds | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2024-10-01 | — | — | US | claimed |
| CN-115109061-B | Tricyclic compounds | 北京加科思新药研发有限公司 | 2025-01-28 | — | — | CN | disclosed |
| US-20250011327-A1 | TRICYCLIC COMPOUNDS | JACOBIO PHARMACEUTICALS CO LTD (CN) | 2025-01-09 | — | — | US | disclosed |
| US-12103929-B2 | Tricyclic compounds | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2024-10-01 | — | — | US | disclosed |
| US-11466005-B2 | Tricyclic compounds | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2022-10-11 | — | — | US | disclosed |
| CN-115109061-A | Tricyclic compounds | 北京加科思新药研发有限公司 | 2022-09-27 | — | — | CN | disclosed |
| US-20220119390-A1 | TRICYCLIC COMPOUNDS | JACOBIO PHARMACEUTICALS CO LTD (CN) | 2022-04-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250011327-A1 | TRICYCLIC COMPOUNDS | BRD4, BET1, BRD3 | METAP2 3272/4885GABRA1 2084/4885GABRG2 2245/4885 |
| US-11466005-B2 | Tricyclic compounds | BRD4, BET1, BRD3 | METAP2 3272/4885GABRA1 2084/4885GABRG2 2245/4885 |
| US-12103929-B2 | Tricyclic compounds | BRD4, BET1, BRD3 | METAP2 3272/4885GABRA1 2084/4885GABRG2 2245/4885 |
| US-20220119390-A1 | TRICYCLIC COMPOUNDS | BRD4, BET1, BRD3 | METAP2 3272/4885GABRA1 2084/4885GABRG2 2245/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.