Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 6/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
| ▸ | CCND1 | P24385 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.41 |
| ▸ | XDH | P47989 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
| ▸ | DAO | P14920 | 1/20 | 0.40 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.40 |
| ▸ | PDE9A | O76083 | 2/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | PDE2A | O00408 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23495851 | 0.78 | METAP2 (0.55) | PARP1KDM4ECDK4CCND1GABRA1 | |
| SCHEMBL29615757 | 0.78 | METAP2 (0.55) | PARP1KDM4ECDK4CCND1GABRA1 | |
| SCHEMBL30273114 | 0.77 | METAP2 (0.62) | PARP1KDM4EADORA3METAP2DAO | |
| SCHEMBL14796578 | 0.77 | METAP2 (0.62) | PARP1KDM4EADORA3METAP2DAO | |
| SCHEMBL14933613 | 0.76 | PARP1 (0.77) | PARP1KDM4ECDK4CCND1GABRA1 | |
| SCHEMBL2411557 | 0.76 | AURKA (0.60) | PARP1CDK4CCND1GABRA1GABRG2 | |
| SCHEMBL12750384 | 0.75 | PARP1 (1.00) | PARP1KDM4ECDK4CCND1GABRA1 | |
| SCHEMBL15338391 | 0.71 | PARP1 (1.00) | PARP1KDM4ECDK4CCND1GABRA1 | |
| SCHEMBL30910462 | 0.71 | PARP1 (1.00) | PARP1KDM4ECDK4CCND1GABRA1 | |
| SCHEMBL17536709 | 0.71 | PARP1 (0.58) | PARP1XDHMETAP2DAOPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9856257-B2 | Pyrazolonaphthyridinone derivatives as MetAP2 inhibitors (methionine aminopeptidase type-2) | SANOFI (FR) | 2018-01-02 | — | — | US | disclosed |
| EP-2978764-B1 | PYRAZOLONAPHTHYRIDINONE DERIVATIVES AS METAP2 INHIBITORS (METHIONINE AMINOPEPTIDASE TYPE-2) | SANOFI SA (FR) | 2017-04-19 | — | — | EP | disclosed |
| US-20160060265-A1 | PYRAZOLONAPHTHYRIDINONE DERIVATIVES AS METAP2 INHIBITORS (METHIONINE AMINOPEPTIDASE TYPE-2) | SANOFI (FR) | 2016-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160060265-A1 | PYRAZOLONAPHTHYRIDINONE DERIVATIVES AS METAP2 INHIBITORS (METHIONINE AMINOPEPTIDASE TYPE-2) | METAP2, METAP1, XPNPEP2 | PARP1 2711/4885KDM4E 2975/4885CDK4 2316/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.