Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 9/20 | 0.97 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.86 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.86 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.86 |
| ▸ | PTGES | O14684 | 1/20 | 0.86 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.86 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.86 |
| ▸ | HPGD | P15428 | 1/20 | 0.86 |
| ▸ | CASP7 | P55210 | 1/20 | 0.86 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | EPRS1 | P07814 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23590305 | 1.00 | DHODH (0.97) | DHODHALDH1A1HIF1AHSD17B10PTGES | |
| SCHEMBL14286200 | 0.93 | HSD17B10 (1.00) | DHODHALDH1A1HIF1AHSD17B10PTGES | |
| SCHEMBL6186359 | 0.90 | DHODH (0.85) | DHODHALDH1A1HIF1AHSD17B10PTGES | |
| SCHEMBL5529524 | 0.90 | HSD17B10 (0.94) | DHODHALDH1A1HIF1AHSD17B10PTGES | |
| SCHEMBL26073753 | 0.89 | DHODH (0.89) | DHODHALDH1A1HIF1AHSD17B10PTGES | |
| SCHEMBL9788828 | 0.87 | DHODH (0.86) | DHODHALDH1A1HIF1AHSD17B10PTGES | |
| SCHEMBL1898306 | 0.86 | HSD17B10 (0.86) | DHODHALDH1A1HIF1AHSD17B10PTGES | |
| SCHEMBL19475331 | 0.85 | ALDH1A1 (0.84) | DHODHALDH1A1HIF1AHSD17B10PTGES | |
| SCHEMBL8231321 | 0.85 | DHODH (1.00) | DHODHALDH1A1HIF1AHSD17B10PTGES | |
| SCHEMBL117422 | 0.85 | PTGES (0.84) | DHODHALDH1A1HIF1AHSD17B10PTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240294477-A1 | METHODS AND COMPOSITIONS FOR INHIBITION OF DIHYDROOROTATE DEHYDROGENASE | OHIO STATE INNOVATION FOUNDATION (US) | 2024-09-05 | — | — | US | disclosed |
| US-11999697-B2 | Methods and compositions for inhibition of dihydroorotate dehydrogenase | OHIO STATE INNOVATION FOUNDATION (US) | 2024-06-04 | — | — | US | disclosed |
| US-11312686-B2 | Methods and compositions for inhibition of dihydroorotate dehydrogenase | OHIO STATE INNOVATION FOUNDATION (US) | 2022-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11312686-B2 | Methods and compositions for inhibition of dihydroorotate dehydrogenase | DHODH, DLD, DPYD | DHODH 1/4885ALDH1A1 72/4885HIF1A 1644/4885 |
| US-20240294477-A1 | METHODS AND COMPOSITIONS FOR INHIBITION OF DIHYDROOROTATE DEHYDROGENASE | DHODH, DLD, DPYD | DHODH 1/4885ALDH1A1 64/4885HIF1A 1566/4885 |
| US-11999697-B2 | Methods and compositions for inhibition of dihydroorotate dehydrogenase | DHODH, DLD, DPYD | DHODH 1/4885ALDH1A1 64/4885HIF1A 1566/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.