Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 5/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.60 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.60 |
| ▸ | SENP1 | Q9P0U3 | 2/20 | 0.57 |
| ▸ | SENP5 | Q96HI0 | 1/20 | 0.57 |
| ▸ | SENP2 | Q9HC62 | 1/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.55 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | CLK1 | P49759 | 1/20 | 0.54 |
| ▸ | NAMPT | P43490 | 3/20 | 0.54 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18641949 | 1.00 | HDAC2 (0.60) | HDAC2HDAC1HDAC3NCOR2SENP1 | |
| SCHEMBL25003385 | 0.84 | HDAC2 (0.66) | HDAC2HDAC1HDAC3NCOR2SENP1 | |
| SCHEMBL29008903 | 0.82 | RAB9A (0.52) | HDAC2HDAC1HDAC3NCOR2SENP1 | |
| SCHEMBL6919078 | 0.82 | HDAC1 (0.70) | HDAC2HDAC1HDAC3NCOR2SENP1 | |
| SCHEMBL28863161 | 0.82 | HDAC1 (0.60) | HDAC2HDAC1HDAC3NCOR2SENP1 | |
| SCHEMBL13494017 | 0.80 | HDAC2 (0.63) | HDAC2HDAC1HDAC3NCOR2SENP1 | |
| SCHEMBL12057508 | 0.80 | HDAC2 (0.67) | HDAC2HDAC1HDAC3NCOR2SENP1 | |
| SCHEMBL13494011 | 0.76 | HDAC2 (0.62) | HDAC2HDAC1HDAC3NCOR2SENP1 | |
| SCHEMBL18641957 | 0.76 | L3MBTL1 (0.76) | HDAC2HDAC1HDAC3RAB9ANAMPT | |
| SCHEMBL25003417 | 0.76 | HDAC2 (1.00) | HDAC2HDAC1HDAC3NCOR2SENP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4116303-A1 | PYRAZOLOPYRIMIDINE DERIVATIVES AS BTK INHIBITORS FOR THE TREATMENT OF CANCER | Loxo Oncology, Inc. (US) | 2023-01-11 | — | — | EP | disclosed |
| EP-3350184-B1 | PYRAZOLOPYRIMIDINE DERIVATIVES AS BTK INHIBITORS FOR THE TREATMENT OF CANCER | LOXO ONCOLOGY INC (US) | 2022-10-19 | — | — | EP | disclosed |
| CN-114685516-A | Pyrazolopyrimidine derivatives as BTK inhibitors for the treatment of cancer | 洛克索肿瘤学股份有限公司 | 2022-07-01 | — | — | CN | disclosed |
| CN-108431007-B | Pyrazolopyrimidine derivatives as BTK inhibitors for the treatment of cancer | 洛克索肿瘤学股份有限公司 | 2022-06-07 | — | — | CN | disclosed |