Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL247150 | 0.87 | CRBN (0.50) | CRBNNPC1MAPK13MAPK12MAPK11 | |
| Hydrochloric Acid SCHEMBL30515324 | 0.86 | CRBN (0.49) | CRBNNPC1MAPK13MAPK12MAPK11 | |
| SCHEMBL1093770 | 0.78 | MAPT (0.53) | CRBNNPC1MAPK13MAPK12MAPK11 | |
| SCHEMBL20073751 | 0.75 | IDH1 (0.43) | CRBN | |
| Acetic Acid SCHEMBL4405059 | 0.74 | GSK3B (0.49) | CRBNNPC1 | |
| SCHEMBL578594 | 0.72 | GSK3B (0.53) | CRBN | |
| SCHEMBL29499281 | 0.72 | GSK3B (0.53) | CRBN | |
| SCHEMBL1093407 | 0.71 | — | — | |
| SCHEMBL1093403 | 0.71 | — | — | |
| SCHEMBL12315102 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109475536-B | Combination of a PD-l antagonist and a RAF inhibitor for the treatment of cancer | 百济神州有限公司 | 2022-05-27 | — | — | CN | disclosed |