Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK7 | Q13164 | 1/20 | 0.47 |
| ▸ | CLK2 | P49760 | 1/20 | 0.46 |
| ▸ | CLK3 | P49761 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | AXL | P30530 | 2/20 | 0.42 |
| ▸ | MERTK | Q12866 | 2/20 | 0.42 |
| ▸ | PAICS | P22234 | 1/20 | 0.41 |
| ▸ | MELK | Q14680 | 3/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23246028 | 1.00 | MAPK7 (0.47) | MAPK7CLK2CLK3DYRK1AAXL | |
| SCHEMBL23245929 | 0.90 | AXL (0.42) | MAPK7CLK2CLK3DYRK1AAXL | |
| SCHEMBL29618374 | 0.90 | AXL (0.42) | MAPK7CLK2CLK3DYRK1AAXL | |
| SCHEMBL29618393 | 0.82 | KCNH2 (0.39) | MAPK7HIF1AEPAS1PDE7A | |
| SCHEMBL23245950 | 0.82 | KCNH2 (0.39) | MAPK7HIF1AEPAS1PDE7A | |
| SCHEMBL23245914 | 0.77 | RAB9A (0.60) | RAB9AL3MBTL1SMN1; SMN2PDE7A | |
| Hydrochloric Acid SCHEMBL29618414 | 0.76 | RAB9A (0.58) | RAB9AL3MBTL1SMN1; SMN2PDE7A | |
| Hydrochloric Acid SCHEMBL23245938 | 0.76 | RAB9A (0.58) | RAB9AL3MBTL1SMN1; SMN2PDE7A | |
| SCHEMBL18713012 | 0.74 | ALDH1A1 (0.45) | MAPK7LTA4HLMNAHRH3 | |
| SCHEMBL1126227 | 0.74 | LMNA (0.57) | CLK2CLK3DYRK1APAICSLTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114502555-B | Derivatives of 4- (imidazo [1,2-a ] pyridin-3-yl) -N- (pyridin-3-yl) pyrimidin-2-amine for the treatment of proliferative diseases and disorders | 常州千红生化制药股份有限公司 | 2024-07-16 | — | — | CN | disclosed |
| EP-4045506-A1 | DERIVATIVES OF 4-(IMIDAZO[1,2-A]PYRIDIN-3-YL)-N-(PYRIDIN-3-YL) PYRIMIDIN-2- AMINE FOR TREATING PROLIFERATIVE DISEASES AND CONDITIONS | Aucentra Therapeutics Pty Ltd (AU) | 2022-08-24 | — | — | EP | disclosed |
| CN-114502555-A | Derivatives of 4- (imidazo [1,2-a ] pyridin-3-yl) -N- (pyridin-3-yl) pyrimidin-2-amines for the treatment of proliferative diseases and disorders | 常州千红生化制药股份有限公司 | 2022-05-13 | — | — | CN | disclosed |