Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 3/20 | 0.45 |
| ▸ | BRD2 | P25440 | 2/20 | 0.45 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 2/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29619013 | 0.92 | BRD4 (0.48) | MAPTBRD4BRD2BRD3ALDH1A1 | |
| SCHEMBL30373962 | 0.83 | LTA4H (0.50) | MAPTALDH1A1MEN1LMNAKMT2A | |
| SCHEMBL26089876 | 0.83 | LTA4H (0.50) | MAPTALDH1A1MEN1LMNAKMT2A | |
| SCHEMBL24398702 | 0.83 | MEN1 (0.46) | MAPTBRD4ALDH1A1MEN1KMT2A | |
| SCHEMBL29619095 | 0.83 | MEN1 (0.46) | MAPTBRD4ALDH1A1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL26090978 | 0.82 | LTA4H (0.49) | MAPTALDH1A1MEN1LMNAKMT2A | |
| Hydrochloric Acid SCHEMBL30373901 | 0.82 | LTA4H (0.49) | MAPTALDH1A1MEN1LMNAKMT2A | |
| SCHEMBL24398370 | 0.80 | BRD4 (0.47) | BRD4BRD2BRD3MEN1KMT2A | |
| SCHEMBL29619121 | 0.79 | ALDH1A1 (0.43) | BRD4ALDH1A1MEN1LMNAKMT2A | |
| SCHEMBL29619131 | 0.79 | PDE5A (0.36) | MAPTBRD4BRD2BRD3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4236942-A1 | ISOXAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2023-09-06 | — | — | EP | disclosed |
| WO-2022093850-A1 | ISOXAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2022-05-05 | — | — | WO | disclosed |