Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.39 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.37 |
| ▸ | PDE5A | O76074 | 2/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | CXCR5 | P32302 | 1/20 | 0.36 |
| ▸ | APLNR | P35414 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CCR6 | P51684 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | EDNRA | P25101 | 2/20 | 0.36 |
| ▸ | EDNRB | P24530 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24398702 | 0.82 | MEN1 (0.46) | ALDH1A1KMT2AMEN1AKR1C3S1PR4 | |
| SCHEMBL29619095 | 0.82 | MEN1 (0.46) | ALDH1A1KMT2AMEN1AKR1C3S1PR4 | |
| SCHEMBL29619010 | 0.79 | MAPT (0.46) | ALDH1A1KMT2AMEN1AKR1C3LMNA | |
| SCHEMBL29619073 | 0.79 | ENPP3 (0.44) | ALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL7866969 | 0.78 | ALDH1A1 (0.58) | ALDH1A1KMT2AMEN1LMNACYP19A1 | |
| SCHEMBL29619126 | 0.78 | MET (0.40) | ALDH1A1RAB9A | |
| SCHEMBL29619013 | 0.78 | BRD4 (0.48) | ALDH1A1KMT2ALMNARAB9ABRD4 | |
| SCHEMBL1903461 | 0.77 | TDP1 (0.48) | ALDH1A1AKR1C3LMNACYP19A1RAB9A | |
| SCHEMBL17467704 | 0.76 | AKR1C3 (0.41) | ALDH1A1KMT2AMEN1AKR1C3BRD4 | |
| SCHEMBL8114936 | 0.76 | CYP19A1 (0.45) | ALDH1A1KMT2AMEN1CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4236942-A1 | ISOXAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2023-09-06 | — | — | EP | disclosed |
| WO-2022093850-A1 | ISOXAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2022-05-05 | — | — | WO | disclosed |