Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.42 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | PFKFB2 | O60825 | 2/20 | 0.39 |
| ▸ | PFKFB1 | P16118 | 2/20 | 0.39 |
| ▸ | PFKFB3 | Q16875 | 2/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24398568 | 1.00 | CHRNB2 (0.43) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA5 | |
| SCHEMBL29619050 | 0.97 | CHRNB2 (0.40) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA5 | |
| SCHEMBL29619060 | 0.97 | CHRNB2 (0.40) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA5 | |
| SCHEMBL29619058 | 0.94 | MAPT (0.42) | CHRNB2CHRNB4CHRNA3CHRNA5MAPT | |
| SCHEMBL29619134 | 0.89 | ABL1 (0.40) | MAPTLMNASMN1; SMN2GABRA5POLB | |
| SCHEMBL29619181 | 0.89 | ABL1 (0.40) | MAPTLMNASMN1; SMN2GABRA5POLB | |
| SCHEMBL31677871 | 0.88 | CHRNB2 (0.45) | CHRNB2CHRNA4CHRNB4CHRNA3POLB | |
| SCHEMBL29619072 | 0.87 | CHRNB2 (0.38) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA5 | |
| SCHEMBL29619108 | 0.87 | CHRNB2 (0.38) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA5 | |
| SCHEMBL29619159 | 0.87 | CHRNB2 (0.38) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240376090-A1 | ISOXAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERED RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2024-11-14 | — | — | US | disclosed |
| EP-4236942-A1 | ISOXAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2023-09-06 | — | — | EP | disclosed |
| WO-2022093850-A1 | ISOXAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2022-05-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240376090-A1 | ISOXAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERED RELATED THERETO | HTR2A, HTR5A, HTR1A | CHRNB2 144/4885CHRNA4 105/4885CHRNB4 304/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.