Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | MCHR1 | Q99705 | 11/20 | 0.48 |
| ▸ | EGFR | P00533 | 4/20 | 0.45 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | MCHR2 | Q969V1 | 3/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL384710 | 0.89 | MCHR1 (0.50) | MCHR1MCHR2 | |
| SCHEMBL520824 | 0.83 | HDAC3 (0.54) | HDAC3HDAC2HDAC1MCHR1EGFR | |
| SCHEMBL29804080 | 0.83 | EGFR (0.56) | HDAC3HDAC2HDAC1MCHR1EGFR | |
| SCHEMBL14534661 | 0.83 | MCHR1 (0.51) | HDAC3HDAC2HDAC1MCHR1EGFR | |
| SCHEMBL110445 | 0.83 | EGFR (0.56) | HDAC3HDAC2HDAC1MCHR1EGFR | |
| SCHEMBL20859441 | 0.81 | HDAC3 (0.50) | HDAC3HDAC2HDAC1MCHR1EGFR | |
| SCHEMBL14594169 | 0.81 | MCHR1 (0.49) | HDAC3HDAC2HDAC1MCHR1EGFR | |
| SCHEMBL13483883 | 0.80 | SIGMAR1 (0.48) | HDAC3HDAC2HDAC1MCHR1EGFR | |
| SCHEMBL30839556 | 0.80 | P2RX7 (0.53) | HDAC3HDAC2HDAC1MCHR1EGFR | |
| SCHEMBL15681624 | 0.79 | HDAC3 (0.61) | HDAC3HDAC2HDAC1MCHR1MCHR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8268868-B2 | 5-pyridinone substituted indazoles | ALBANY MOLECULAR RESEARCH, INC. (US) | 2012-09-18 | — | — | US | disclosed |
| US-8268868-B2 | 5-pyridinone substituted indazoles | ALBANY MOLECULAR RESEARCH, INC. (US) | 2012-09-18 | — | — | US | disclosed |
| US-8268868-B2 | 5-pyridinone substituted indazoles | ALBANY MOLECULAR RESEARCH, INC. (US) | 2012-09-18 | — | — | US | disclosed |
| US-20100105679-A1 | 5-PYRIDINONE SUBSTITUTED INDAZOLES | ALBANY MOLECULAR RESEARCH, INC. (US) | 2010-04-29 | — | — | US | disclosed |
| US-20100105679-A1 | 5-PYRIDINONE SUBSTITUTED INDAZOLES | ALBANY MOLECULAR RESEARCH, INC. (US) | 2010-04-29 | — | — | US | disclosed |
| US-20100105679-A1 | 5-PYRIDINONE SUBSTITUTED INDAZOLES | ALBANY MOLECULAR RESEARCH, INC. (US) | 2010-04-29 | — | — | US | disclosed |
| CN-101679348-A | 5-pyridone substituted indazoles | AMR TECHNOLOGY INC | 2010-03-24 | — | — | CN | disclosed |
| EP-2121654-A1 | 5-PYRIDINONE SUBSTITUTED INDAZOLES | Albany Molecular Research, Inc. (US) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008086404-A1 | 5-PYRIDINONE SUBSTITUTED INDAZOLES | ALBANY MOLECULAR RESEARCH, INC. (US) | 2008-07-17 | — | — | WO | disclosed |
| WO-2008086404-A1 | 5-PYRIDINONE SUBSTITUTED INDAZOLES | ALBANY MOLECULAR RESEARCH, INC. (US) | 2008-07-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100105679-A1 | 5-PYRIDINONE SUBSTITUTED INDAZOLES | CYP3A5, PDXK, PNPO | HDAC3 932/4885HDAC2 1520/4885HDAC1 1202/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.