Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.36 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.36 |
| ▸ | ITGAL | P20701 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CRHBP | P24387 | 2/20 | 0.32 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22827024 | 1.00 | MAPT (0.38) | MAPTLMNAHTTBLMKDM4E | |
| SCHEMBL14720885 | 0.83 | AOC3 (0.42) | MAPTMEN1KMT2ATDP1L3MBTL1 | |
| SCHEMBL8405592 | 0.78 | ADRA2A (0.46) | MAPTLMNAHTTKDM4EGAA | |
| SCHEMBL4923363 | 0.78 | MAPT (0.39) | MAPTLMNAHTTKDM4EGAA | |
| Hydrochloric Acid SCHEMBL18686536 | 0.77 | MAPT (0.42) | MAPTLMNAHTTKDM4EGAA | |
| SCHEMBL10188136 | 0.75 | MAPT (0.37) | MAPTLMNAHTTKDM4EGAA | |
| SCHEMBL25166705 | 0.75 | HTT (0.38) | MAPTLMNAHTTBLMKDM4E | |
| SCHEMBL25166294 | 0.75 | LMNA (0.38) | MAPTLMNAHTTBLMKDM4E | |
| SCHEMBL30329793 | 0.75 | LMNA (0.38) | MAPTLMNAHTTBLMKDM4E | |
| SCHEMBL25166334 | 0.75 | LMNA (0.38) | MAPTLMNAHTTBLMKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112469713-B | Aryl phosphorus oxide derivative inhibitor, preparation method and application thereof | 江苏豪森药业集团有限公司 | 2023-09-01 | — | — | CN | disclosed |
| CN-116234556-A | Crystal form of aryl phosphorus oxide derivative free alkali and preparation method and application thereof | 江苏豪森药业集团有限公司 | 2023-06-06 | — | — | CN | disclosed |
| WO-2022127807-A1 | CRYSTAL FORM OF ARYL PHOSPHORUS OXIDE DERIVATIVE FREE BASE, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | 江苏豪森药业集团有限公司 | 2022-06-23 | — | — | WO | disclosed |
| CN-114644654-A | Oxidized aryl phosphorus derivative, acid salt or crystal form thereof, and preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2022-06-21 | — | — | CN | disclosed |