Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
| ▸ | CCND1 | P24385 | 1/20 | 0.42 |
| ▸ | PNMT | P11086 | 1/20 | 0.41 |
| ▸ | CD44 | P16070 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 7/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | HTR5A | P47898 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.37 |
| ▸ | HTR2B | P41595 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5848306 | 0.85 | MEN1 (0.46) | MEN1KMT2AALOX15USP2ALDH1A1 | |
| SCHEMBL18322642 | 0.83 | ALDH1A1 (0.42) | MEN1KMT2AALOX15USP2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL5849987 | 0.80 | SIGMAR1 (0.50) | MEN1KMT2AALOX15USP2ALDH1A1 | |
| SCHEMBL5787260 | 0.79 | ADRA1D (0.39) | MEN1KMT2AALOX15USP2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL5848138 | 0.79 | ALDH1A1 (0.44) | MEN1KMT2AALOX15USP2ALDH1A1 | |
| SCHEMBL15522880 | 0.79 | MEN1 (0.67) | MEN1KMT2AALOX15USP2ALDH1A1 | |
| SCHEMBL15523667 | 0.77 | MEN1 (0.50) | MEN1KMT2AALOX15USP2ALDH1A1 | |
| SCHEMBL11768786 | 0.76 | ALDH1A1 (0.47) | MEN1KMT2AALOX15USP2ALDH1A1 | |
| SCHEMBL1027312 | 0.76 | ALDH1A1 (0.70) | MEN1KMT2AALOX15USP2ALDH1A1 | |
| SCHEMBL5848149 | 0.74 | KMT2A (0.46) | MEN1KMT2AALOX15ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7763605-B2 | [1,4]benzodiazepines as vasopressin V2 receptor antagonists | JANSSEN PHARMACEUTICA, N.V. (BE) | 2010-07-27 | — | — | US | disclosed |
| EP-1809296-A4 | NOVEL [1,4]BENZODIAZEPINES AS VASOPRESSIN V2 RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2009-03-11 | — | — | EP | disclosed |
| EP-1809296-A2 | NOVEL [1,4]BENZODIAZEPINES AS VASOPRESSIN V2 RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-07-25 | — | — | EP | disclosed |
| US-20060116367-A1 | Novel [1,4]benzodiazepines as vasopressin V2 receptor antagonists | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-06-01 | — | — | US | disclosed |
| WO-2006049984-A2 | NOVEL [1,4]BENZODIAZEPINES AS VASOPRESSIN V2 RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-05-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060116367-A1 | Novel [1,4]benzodiazepines as vasopressin V2 receptor antagonists | AVPR2, AVPR1B, AVPR1A | MEN1 3414/4885KMT2A 4159/4885ALOX15 1907/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.