SCHEMBL29620987

SCHEMBL29620987

CC1Cc2cc(C(F)(F)F)ccc2C1=O

nearest known ligand 0.51

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
ACHE P22303 9/20 0.51
TDP2 O95551 1/20 0.46
HTR2A P28223 4/20 0.46
HTR2C P28335 4/20 0.46
HTR2B P41595 4/20 0.46
AADAT Q8N5Z0 1/20 0.41
CYP26A1 O43174 1/20 0.40
PNMT P11086 3/20 0.40
PARP1 P09874 1/20 0.40
PARP10 Q53GL7 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21132327 0.87 ACHE (0.63) ACHETDP2HTR2AHTR2CHTR2B
SCHEMBL28878592 0.85 ACHE (0.53) ACHE
SCHEMBL11855191 0.80 TDP2 (0.46) TDP2HTR2AHTR2CHTR2BAADAT
SCHEMBL569403 0.77 ACHE (0.74) ACHEHTR2AHTR2CHTR2B
SCHEMBL6641298 0.77 CYP26A1 (0.44) ACHETDP2HTR2AHTR2CHTR2B
SCHEMBL2484416 0.75 ACHE (0.73) ACHEHTR2AHTR2CHTR2BPARP10
SCHEMBL5952403 0.75 ACHE (0.43) ACHETDP2HTR2AHTR2CHTR2B
SCHEMBL28736086 0.75 KDM4E (0.46) TDP2HTR2AHTR2CHTR2BCYP26A1
SCHEMBL5951501 0.74 ACHE (0.49) ACHETDP2CYP26A1
SCHEMBL1500072 0.74 METAP1 (0.56) ACHETDP2PNMTPARP10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114539055-A Method for realizing phase transfer catalysis beta-dicarbonyl compound alkylation reaction by using microchannel reactor 西安近代化学研究所 2022-05-27 CN disclosed