SCHEMBL29623129

SCHEMBL29623129

O=c1c2cc(Cl)ccc2nc(Nc2ccc(CN3CC(C(F)F)C3)cc2)n1-c1ccccc1

nearest known ligand 0.42

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
ACP1 P24666 1/20 0.39
P2RX3 P56373 2/20 0.37
MAT2A P31153 1/20 0.37
HTR7 P34969 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23065248 1.00 ACP1 (0.39) ACP1P2RX3MAT2AHTR7
SCHEMBL24089897 0.90 ACP1 (0.40) ACP1MAT2A
SCHEMBL29623150 0.90 ACP1 (0.40) ACP1MAT2A
SCHEMBL23064459 0.88 LMNA (0.39) ACP1
SCHEMBL23065257 0.86 DRD2 (0.39)
SCHEMBL29623121 0.86 DRD2 (0.39)
SCHEMBL23065073 0.85 ACP1 (0.48) ACP1
SCHEMBL29623137 0.84 ACP1 (0.40) ACP1P2RX3HTR7
SCHEMBL23045336 0.84 ACP1 (0.40) ACP1P2RX3HTR7
SCHEMBL23065072 0.84 ACP1 (0.52) ACP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114650986-A 2-aminoquinazolinone derivatives 住友制药株式会社 2022-06-21 CN claimed
CN-114650986-A 2-aminoquinazolinone derivatives 住友制药株式会社 2022-06-21 CN disclosed