Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | BCL9 | O00512 | 1/20 | 0.38 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29623674 | 0.84 | LMNA (0.46) | MAPTLMNAALDH1A1GAASMN1; SMN2 | |
| SCHEMBL21932140 | 0.81 | ALDH1A1 (0.40) | MAPTMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL28032524 | 0.79 | ALDH1A1 (0.56) | MAPTMEN1KMT2ALMNAALOX12 | |
| SCHEMBL2999739 | 0.77 | MAPT (0.54) | MAPTMEN1KMT2ALMNACYP19A1 | |
| SCHEMBL3146623 | 0.76 | MAPT (0.49) | MAPTMEN1KMT2ACYP19A1ALDH1A1 | |
| SCHEMBL28546052 | 0.76 | ATM (0.44) | MAPTMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL3159673 | 0.73 | MAPT (0.50) | MAPTMEN1KMT2ALMNACYP19A1 | |
| SCHEMBL5624112 | 0.72 | ALDH1A1 (0.51) | MAPTMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL3143812 | 0.71 | MAPT (0.47) | MAPTMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL21932234 | 0.70 | MAPT (0.45) | MAPTMEN1KMT2ALMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3986468-A1 | ANTIB0DY-ALK5 INHIBITOR CONJUGATES AND THEIR USES | Synthis Therapeutics, Inc. (US) | 2022-04-27 | — | — | EP | disclosed |