Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Glycerin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.47 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.45 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | ACACA | Q13085 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycerin SCHEMBL15061 | 1.00 | LMNA (0.60) | LMNAALDH1A1FFAR3LCKFYN | |
| Glycerin SCHEMBL203757 | 1.00 | LMNA (0.60) | LMNAALDH1A1FFAR3LCKFYN | |
| Glycerin SCHEMBL30460570 | 1.00 | LMNA (0.60) | LMNAALDH1A1FFAR3LCKFYN | |
| Glycerin SCHEMBL33458 | 1.00 | LMNA (0.60) | LMNAALDH1A1FFAR3LCKFYN | |
| Glycerin SCHEMBL1685690 | 1.00 | LMNA (0.60) | LMNAALDH1A1FFAR3LCKFYN | |
| Glycerin SCHEMBL1685695 | 1.00 | LMNA (0.60) | LMNAALDH1A1FFAR3LCKFYN | |
| Glycerin SCHEMBL1685689 | 1.00 | LMNA (0.60) | LMNAALDH1A1FFAR3LCKFYN | |
| Glycerin SCHEMBL31032269 | 1.00 | LMNA (0.60) | LMNAALDH1A1FFAR3LCKFYN | |
| Glycerin SCHEMBL8151443 | 1.00 | LMNA (0.60) | LMNAALDH1A1FFAR3LCKFYN | |
| Glycerin SCHEMBL29793596 | 1.00 | LMNA (0.60) | LMNAALDH1A1FFAR3LCKFYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114469772-A | Anti-inflammatory and relieving composition based on targeted red repairing and preparation method thereof | 广州集妍化妆品科技有限公司 | 2022-05-13 | — | — | CN | disclosed |