Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Promethazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 3/20 | 0.97 |
| ▸ | LMNA | P02545 | 4/20 | 1.00 |
| ▸ | MAPT | P10636 | 3/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 3/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 3/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 3/20 | 1.00 |
| ▸ | GFER | P55789 | 3/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 2/20 | 1.00 |
| ▸ | GMNN | O75496 | 1/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.97 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.97 |
| ▸ | HTR1A | P08908 | 6/20 | 0.97 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.97 |
| ▸ | ADRA1A | P35348 | 6/20 | 0.97 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.97 |
| ▸ | DRD3 | P35462 | 6/20 | 0.97 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.97 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Promethazine SCHEMBL2962420 | 1.00 | LMNA (1.00) | LMNAMAPTSMN1; SMN2MAPK1HIF1A | |
| Promethazine SCHEMBL29390401 | 1.00 | LMNA (1.00) | LMNAMAPTSMN1; SMN2MAPK1HIF1A | |
| Promethazine SCHEMBL5425141 | 1.00 | LMNA (1.00) | LMNAMAPTSMN1; SMN2MAPK1HIF1A | |
| Promethazine SCHEMBL27559626 | 1.00 | LMNA (1.00) | LMNAMAPTSMN1; SMN2MAPK1HIF1A | |
| Promethazine SCHEMBL41904 | 1.00 | LMNA (1.00) | LMNAMAPTSMN1; SMN2MAPK1HIF1A | |
| Promethazine SCHEMBL3991025 | 0.98 | LMNA (0.97) | LMNAMAPTSMN1; SMN2MAPK1HIF1A | |
| (S)-Promethazine SCHEMBL2900853 | 0.98 | CYP2D6 (1.00) | LMNAMAPTSMN1; SMN2MAPK1HIF1A | |
| Promethazine SCHEMBL29372077 | 0.98 | CYP2D6 (1.00) | LMNAMAPTSMN1; SMN2MAPK1HIF1A | |
| Promethazine SCHEMBL26777 | 0.98 | CYP2D6 (1.00) | LMNAMAPTSMN1; SMN2MAPK1HIF1A | |
| Promethazine SCHEMBL4700 | 0.98 | CYP2D6 (1.00) | LMNAMAPTSMN1; SMN2MAPK1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1960781-A | Therapeutic combination for treatment of alzheimers disease | WARNER LAMBERT CO (US) | 2007-05-09 | — | — | CN | disclosed |
| EP-1737539-A1 | THERAPEUTIC COMBINATION FOR TREATMENT OF ALZHEIMERS DISEASE | Warner-Lambert Company LLC (US) | 2007-01-03 | — | — | EP | disclosed |
| WO-2005099823-A1 | THERAPEUTIC COMBINATION FOR TREATMENT OF ALZHEIMERS DISEASE | WARNER-LAMBERT COMPANY LLC (US) | 2005-10-27 | — | — | WO | disclosed |
| EP-1014977-A1 | DIAGNOSIS OF MIGRAINE WITH AURA, DEPRESSION AND ANXIETY FROM ALLELIC VARIATIONS IN DOPAMINERGIC GENES | GLAXO GROUP LIMITED (GB) | 2000-07-05 | — | — | EP | disclosed |
| EP-1014977-A4 | DIAGNOSIS OF MIGRAINE WITH AURA, DEPRESSION AND ANXIETY FROM ALLELIC VARIATIONS IN DOPAMINERGIC GENES | GLAXO GROUP LTD (GB) | 2000-07-05 | — | — | EP | disclosed |
| WO-1998007426-A1 | DIAGNOSIS OF MIGRAINE WITH AURA, DEPRESSION AND ANXIETY FROM ALLELIC VARIATIONS IN DOPAMINERGIC GENES | GLAXO GROUP, LTD. (GB) | 1998-02-26 | — | — | WO | disclosed |