Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Promethazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 3/20 | 0.97 |
| ▸ | LMNA | P02545 | 4/20 | 1.00 |
| ▸ | MAPT | P10636 | 3/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 3/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 3/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 3/20 | 1.00 |
| ▸ | GFER | P55789 | 3/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 2/20 | 1.00 |
| ▸ | GMNN | O75496 | 1/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.97 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.97 |
| ▸ | HTR1A | P08908 | 6/20 | 0.97 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.97 |
| ▸ | ADRA1A | P35348 | 6/20 | 0.97 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.97 |
| ▸ | DRD3 | P35462 | 6/20 | 0.97 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.97 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Promethazine SCHEMBL5501515 | 1.00 | LMNA (1.00) | LMNAMAPTSMN1; SMN2MAPK1HIF1A | |
| Promethazine SCHEMBL2962420 | 1.00 | LMNA (1.00) | LMNAMAPTSMN1; SMN2MAPK1HIF1A | |
| Promethazine SCHEMBL29390401 | 1.00 | LMNA (1.00) | LMNAMAPTSMN1; SMN2MAPK1HIF1A | |
| Promethazine SCHEMBL5425141 | 1.00 | LMNA (1.00) | LMNAMAPTSMN1; SMN2MAPK1HIF1A | |
| Promethazine SCHEMBL27559626 | 1.00 | LMNA (1.00) | LMNAMAPTSMN1; SMN2MAPK1HIF1A | |
| Promethazine SCHEMBL3991025 | 0.98 | LMNA (0.97) | LMNAMAPTSMN1; SMN2MAPK1HIF1A | |
| (S)-Promethazine SCHEMBL2900853 | 0.98 | CYP2D6 (1.00) | LMNAMAPTSMN1; SMN2MAPK1HIF1A | |
| Promethazine SCHEMBL29372077 | 0.98 | CYP2D6 (1.00) | LMNAMAPTSMN1; SMN2MAPK1HIF1A | |
| Promethazine SCHEMBL26777 | 0.98 | CYP2D6 (1.00) | LMNAMAPTSMN1; SMN2MAPK1HIF1A | |
| Promethazine SCHEMBL4700 | 0.98 | CYP2D6 (1.00) | LMNAMAPTSMN1; SMN2MAPK1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 10560 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260076872-A1 | POLYMER VIALS WITH SUBSTANTIALLY FLAT BOTTOMS AND INJECTION STRETCH BLOW MOLDING METHODS FOR MAKING THE SAME | SIO2 MEDICAL PRODUCTS LLC (US) | 2026-03-19 | — | — | US | claimed |
| US-20250275924-A1 | Anticholinergic Agents and Muscarinic Agonists for the Treatment of Demodex Related Conditions | ATTILLAPS HOLDINGS INC. | 2025-09-04 | — | — | US | claimed |
| EP-3634044-B1 | DISCONTINUOUS RECEPTION METHOD, TERMINAL DEVICE AND NETWORK DEVICE | GUANGDONG OPPO MOBILE TELECOMMUNICATIONS CORP LTD (CN) | 2025-08-20 | — | — | EP | claimed |
| US-20250248940-A1 | Biopolymer Formulations for Drug Delivery | 11584022 CANADA INC. (CA) | 2025-08-07 | — | — | US | claimed |
| US-20250242092-A1 | SiOx BARRIER FOR PHARMACEUTICAL PACKAGE AND COATING PROCESS | SIO2 MEDICAL PRODUCTS INC (US) | 2025-07-31 | — | — | US | claimed |
| CN-120161131-A | Method for detecting related substances of promethazine hydrochloride bulk drug | 江苏东科康德药业有限公司 | 2025-06-17 | — | — | CN | claimed |
| CN-116179285-B | Liquid detergent for automatic dish-washing machine | 芜湖美的智能厨电制造有限公司 | 2025-05-27 | — | — | CN | claimed |
| CN-118598824-B | Synthesis method of promethazine hydrochloride | 海南海和制药有限公司 | 2025-05-16 | — | — | CN | claimed |
| EP-4547280-A1 | BIOPOLYMER FORMULATIONS FOR DRUG DELIVERY | 11584022 Canada Inc. (CA) | 2025-05-07 | — | — | EP | claimed |
| CN-119789873-A | Biopolymer formulation for drug delivery | 11584022加拿大有限公司 | 2025-04-08 | — | — | CN | claimed |
| EP-0189861-A2 | Percutaneous absorption accelerator for ionic water-soluble medicine | SHOWA DENKO KABUSHIKI KAISHA (JP) | 1986-08-06 | — | — | EP | claimed |
| EP-0056825-B1 | A PROCESS FOR PRODUCING A PHARMACEUTICAL CAPSULE HAVING ENTERIC PROPERTIES | Capsugel A.G. (CH) | 1984-12-05 | — | — | EP | claimed |
| EP-0046893-B1 | SHINGLER WHEEL FOR SHEET FEED APPARATUS AND SHEET FEED APPARATUS COMPRISING THE SAME | International Business Machines Corporation (US) | 1984-11-28 | — | — | EP | claimed |
| US-4334526-A | Method for administering a dissociative, unconscious type of anesthesia | HAMACHER EDWARD N | 1982-06-15 | — | — | US | claimed |
| US-4299726-A | Process for preparing whole blood reference controls having long term stability, preconditioning diluent and media therefor | COULTER ELECTRONICS, INC. (US) | 1981-11-10 | — | — | US | claimed |
| US-4269835-A | Nasal composition for relieving nasal distress | WHITTLE BARRY J | 1981-05-26 | — | — | US | claimed |
| US-4256743-A | PHENOTHIAZINES, ETHYLENEDIAMINES, INDENES | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 1981-03-17 | — | — | US | claimed |
| US-4246894-A | Method and system for administering a dissociative, unconscious type of anesthesia | HAMACHER EDWARD N | 1981-01-27 | — | — | US | claimed |
| US-4070463-A | PROMETHAZINE HYDROCHLORIDE, 1-EPHEDRINE SULFATE | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 1978-01-24 | — | — | US | claimed |
| US-3981398-A | Aid in the management of clinical emergencies in medical and dental practices and other circumstances | Pienaar, Hendrik Lukas (ZA) | 1976-09-21 | — | — | US | claimed |