Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.36 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 5/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.33 |
| ▸ | XDH | P47989 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.32 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4201391 | 0.77 | KDM4E (1.00) | KDM4EALDH1A1HPGDCYP17A1HIF1A | |
| SCHEMBL30117642 | 0.74 | KDM4E (0.75) | KDM4EKDM4DALDH1A1HPGDCYP17A1 | |
| SCHEMBL29624191 | 0.73 | KDM4E (0.73) | KDM4EALDH1A1HPGDPDE4B | |
| SCHEMBL7701732 | 0.73 | KDM4E (0.73) | KDM4EKDM4DCDK2XDHALDH1A1 | |
| SCHEMBL21090450 | 0.72 | KDM4E (0.50) | KDM4EKDM4DIRAK4 | |
| SCHEMBL29387290 | 0.71 | KDM4E (0.51) | KDM4EXDHALDH1A1 | |
| SCHEMBL18366927 | 0.71 | KDM4E (0.51) | KDM4EXDHALDH1A1 | |
| SCHEMBL27254297 | 0.71 | KDM4E (0.59) | KDM4EKDM4DALDH1A1HPGDCYP17A1 | |
| SCHEMBL10176225 | 0.70 | KDM4E (0.67) | KDM4EALDH1A1HPGD | |
| SCHEMBL5683198 | 0.69 | KDM4E (0.67) | KDM4EKDM4DALDH1A1HPGDIRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4003991-A1 | HETEROARYL-SUBSTITUTED PYRAZOLO-PYRIDINE PROTEIN KINASE INHIBITORS FOR PROMOTING LIVER REGENERATION OR REDUCING OR PREVENTING HEPATOCYTE DEATH | HepaRegeniX GmbH (DE) | 2022-06-01 | — | — | EP | disclosed |