Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | INSR | P06213 | 1/20 | 0.38 |
| ▸ | ROS1 | P08922 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.38 |
| ▸ | PRKACA | P17612 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19377806 | 0.88 | POLB (0.45) | POLBGAATSHRSMN1; SMN2MAPK14 | |
| SCHEMBL29626100 | 0.88 | POLB (0.45) | POLBGAATSHRSMN1; SMN2MAPK14 | |
| SCHEMBL30672148 | 0.85 | MERTK (0.42) | SMN1; SMN2ALDH1A1PLK4ROCK2RPS6KA5 | |
| SCHEMBL19377928 | 0.83 | NPC1 (0.51) | POLBGAATSHRSMN1; SMN2MEN1 | |
| SCHEMBL31051678 | 0.83 | NPC1 (0.51) | POLBGAATSHRSMN1; SMN2MEN1 | |
| SCHEMBL30672466 | 0.82 | ALDH1A1 (0.43) | POLBSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL30672493 | 0.81 | ALDH1A1 (0.43) | POLBGAATSHRSMN1; SMN2MEN1 | |
| SCHEMBL30672459 | 0.81 | SMN1; SMN2 (0.38) | POLBGAATSHRSMN1; SMN2MAPK14 | |
| SCHEMBL30672509 | 0.79 | PLAUR (0.36) | POLBSMN1; SMN2MAPK14MEN1KMT2A | |
| SCHEMBL30672471 | 0.78 | MERTK (0.47) | SMN1; SMN2MAPK14ALDH1A1MAP4K4PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3436461-B1 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | INCYTE CORP (US) | 2023-11-01 | — | — | EP | disclosed |
| CN-114456175-A | Pyrrolotriazine compounds as TAM inhibitors | 因赛特公司 | 2022-05-10 | — | — | CN | disclosed |
| CN-114456176-A | Pyrrolotriazine compounds as TAM inhibitors | 因赛特公司 | 2022-05-10 | — | — | CN | disclosed |