Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MERTK | Q12866 | 8/20 | 0.68 |
| ▸ | AXL | P30530 | 5/20 | 0.68 |
| ▸ | TYRO3 | Q06418 | 10/20 | 0.42 |
| ▸ | ACVRL1 | P37023 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28667889 | 0.83 | MERTK (0.71) | MERTKAXLTYRO3 | |
| SCHEMBL19377669 | 0.81 | MERTK (1.00) | MERTKAXLTYRO3 | |
| SCHEMBL28661888 | 0.78 | TYRO3 (0.68) | MERTKAXLTYRO3 | |
| SCHEMBL29626306 | 0.72 | ACVRL1 (0.52) | MERTKAXLTYRO3ACVRL1 | |
| SCHEMBL29626096 | 0.69 | AXL (0.53) | MERTKAXLTYRO3ACVRL1 | |
| SCHEMBL29626256 | 0.68 | AXL (0.52) | MERTKAXLTYRO3ACVRL1 | |
| SCHEMBL29626173 | 0.67 | TYRO3 (0.66) | MERTKAXLTYRO3 | |
| SCHEMBL29626184 | 0.67 | AXL (0.51) | MERTKAXLTYRO3ACVRL1 | |
| SCHEMBL19377764 | 0.67 | ACVRL1 (0.64) | MERTKAXLACVRL1 | |
| SCHEMBL29626192 | 0.66 | AXL (0.64) | MERTKAXLTYRO3ACVRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114456175-B | Pyrrolotriazine compounds as TAM inhibitors | 因赛特公司 | 2024-09-03 | — | — | CN | disclosed |
| CN-114456176-B | Pyrrolotriazine compounds as TAM inhibitors | 因赛特公司 | 2024-08-30 | — | — | CN | disclosed |
| CN-114456175-A | Pyrrolotriazine compounds as TAM inhibitors | 因赛特公司 | 2022-05-10 | — | — | CN | disclosed |
| CN-114456176-A | Pyrrolotriazine compounds as TAM inhibitors | 因赛特公司 | 2022-05-10 | — | — | CN | disclosed |