Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MERTK | Q12866 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MARS1 | P56192 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | MAT2A | P31153 | 2/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29626186 | 0.85 | POLB (0.44) | NPSR1SMN1; SMN2ALDH1A1KDM4EHPGD | |
| SCHEMBL30672466 | 0.82 | ALDH1A1 (0.43) | NPSR1SMN1; SMN2ALDH1A1KDM4EHPGD | |
| SCHEMBL30672493 | 0.81 | ALDH1A1 (0.43) | NPSR1SMN1; SMN2ALDH1A1KDM4EHPGD | |
| SCHEMBL30672459 | 0.81 | SMN1; SMN2 (0.38) | NPSR1SMN1; SMN2ALDH1A1KDM4EHPGD | |
| SCHEMBL30672509 | 0.79 | PLAUR (0.36) | MERTKNPSR1SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL30672116 | 0.78 | BRD4 (0.41) | MERTKNPSR1SMN1; SMN2HSD17B10ALDH1A1 | |
| SCHEMBL30672471 | 0.78 | MERTK (0.47) | MERTKSMN1; SMN2HSD17B10ALDH1A1KDM4E | |
| SCHEMBL30672525 | 0.78 | TGFBR1 (0.39) | SMN1; SMN2ALDH1A1KDM4EHPGDMARS1 | |
| SCHEMBL30185699 | 0.77 | HPGD (0.49) | NPSR1SMN1; SMN2ALDH1A1KDM4EHPGD | |
| SCHEMBL30672112 | 0.76 | MKNK1 (0.46) | MAPK1ALDH1A1KDM4EHPGDMAT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3436461-B1 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | INCYTE CORP (US) | 2023-11-01 | — | — | EP | disclosed |